Universität zu Köln

Alawbathani, Salem, Batool, Mehreen, Fleckhaus, Jan, Hamad, Sarkawt ORCID: 0000-0002-5155-9467, Hassenrueck, Floyd, Hou, Yanhong, Li, Xia ORCID: 0000-0001-7765-0333, Salmanton-Garcia, Jon, Ullah, Sami, Wieters, Frederique and Michel, Martin C. (2021). A teaching tool about the fickle p value and other statistical principles based on real-life data. Naunyn-Schmiedebergs Arch. Pharmacol., 394 (6). S. 1315 - 1320. NEW YORK: SPRINGER. ISSN 1432-1912

Full text not available from this repository.

Abstract

A poor understanding of statistical analysis has been proposed as a key reason for lack of replicability of many studies in experimental biomedicine. While several authors have demonstrated the fickleness of calculated p values based on simulations, we have experienced that such simulations are difficult to understand for many biomedical scientists and often do not lead to a sound understanding of the role of variability between random samples in statistical analysis. Therefore, we as trainees and trainers in a course of statistics for biomedical scientists have used real data from a large published study to develop a tool that allows scientists to directly experience the fickleness of p values. A tool based on a commonly used software package was developed that allows using random samples from real data. The tool is described and together with the underlying database is made available. The tool has been tested successfully in multiple other groups of biomedical scientists. It can also let trainees experience the impact of randomness, sample sizes and choice of specific statistical test on measured p values. We propose that live exercises based on real data will be more impactful in the training of biomedical scientists on statistical concepts.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Alawbathani, Salem UNSPECIFIED UNSPECIFIED UNSPECIFIED Batool, Mehreen UNSPECIFIED UNSPECIFIED UNSPECIFIED Fleckhaus, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Hamad, Sarkawt UNSPECIFIED orcid.org/0000-0002-5155-9467 UNSPECIFIED Hassenrueck, Floyd UNSPECIFIED UNSPECIFIED UNSPECIFIED Hou, Yanhong UNSPECIFIED UNSPECIFIED UNSPECIFIED Li, Xia UNSPECIFIED orcid.org/0000-0001-7765-0333 UNSPECIFIED Salmanton-Garcia, Jon UNSPECIFIED UNSPECIFIED UNSPECIFIED Ullah, Sami UNSPECIFIED UNSPECIFIED UNSPECIFIED Wieters, Frederique UNSPECIFIED UNSPECIFIED UNSPECIFIED Michel, Martin C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-589014
DOI:	10.1007/s00210-020-02045-3
Journal or Publication Title:	Naunyn-Schmiedebergs Arch. Pharmacol.
Volume:	394
Number:	6
Page Range:	S. 1315 - 1320
Date:	2021
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-1912
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Pharmacology & Pharmacy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58901