'Sullivan, David O., Stanczak, Michal A., Villa, Matteo, Uhl, Franziska M., Corrado, Mauro, Geltink, Ramon I. Klein, Sanin, David E., Apostolova, Petya ORCID: 0000-0002-3856-5109, Rana, Nisha, Edwards-Hicks, Joy, Grzes, Katarzyna M., Kabat, Agnieszka M., Kyle, Ryan L., Fabri, Mario, Curtis, Jonathan D., Buck, Michael D., Patterson, Annette E., Regina, Annamaria, Field, Cameron S., Baixauli, Francesc, Puleston, Daniel J., Pearce, Edward J., Zeiser, Robert and Pearce, Erika L. (2021). Fever supports CD8+effector T cell responses by mitochondrial translation. Proc. Natl. Acad. Sci. U. S. A., 118 (25). WASHINGTON: NATL ACAD SCIENCES. ISSN 0027-8424

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Abstract

Fever can provide a survival advantage during infection. Metabolic processes are sensitive to environmental conditions, but the effect of fever on T cell metabolism is not well characterized. We show that in activated CD8* T cells, exposure to febrile temperature (39 degrees C) augmented metabolic activity and T cell effector functions, despite having a limited effect on proliferation or activation marker expression. Transcriptional profiling revealed an up-regulation of mitochondrial pathways, which was consistent with increased mass and metabolism observed in T cells exposed to 39 degrees C. Through in vitro and in vivo models, we determined that mitochondrial translation is integral to the enhanced metabolic activity and function of CD8* T cells exposed to febrile temperature. Transiently exposing donor lymphocytes to 39 degrees C prior to infusion in a myeloid leukemia mouse model conferred enhanced therapeutic efficacy, raising the possibility that exposure of T cells to febrile temperatures could have clinical potential.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
'Sullivan, David O.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stanczak, Michal A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Villa, MatteoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Uhl, Franziska M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Corrado, MauroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Geltink, Ramon I. KleinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sanin, David E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Apostolova, PetyaUNSPECIFIEDorcid.org/0000-0002-3856-5109UNSPECIFIED
Rana, NishaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Edwards-Hicks, JoyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grzes, Katarzyna M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kabat, Agnieszka M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kyle, Ryan L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fabri, MarioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Curtis, Jonathan D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buck, Michael D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Patterson, Annette E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Regina, AnnamariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Field, Cameron S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baixauli, FrancescUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Puleston, Daniel J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pearce, Edward J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zeiser, RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pearce, Erika L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-589113
DOI: 10.1073/pnas.2023752118
Journal or Publication Title: Proc. Natl. Acad. Sci. U. S. A.
Volume: 118
Number: 25
Date: 2021
Publisher: NATL ACAD SCIENCES
Place of Publication: WASHINGTON
ISSN: 0027-8424
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
EFFECTOR; TEMPERATURE; DIFFERENTIATION; BIOGENESIS; METABOLISMMultiple languages
Multidisciplinary SciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/58911

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