Universität zu Köln

Jobe, Timothy O., Yu, Qi, Hauser, Felix, Xie, Qingqing, Meng, Yuan, Maassen, Tim, Kopriva, Stanislav ORCID: 0000-0002-7416-6551 and Schroeder, Julian I. (2021). The SLIM1 transcription factor is required for arsenic resistance in Arabidopsis thaliana. FEBS Lett., 595 (12). S. 1696 - 1708. HOBOKEN: WILEY. ISSN 1873-3468

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Abstract

The transcriptional regulators of arsenic-induced gene expression remain largely unknown. Sulfur assimilation is tightly linked with arsenic detoxification. Here, we report that mutant alleles in the SLIM1 transcription factor are substantially more sensitive to arsenic than cadmium. Arsenic treatment caused high levels of oxidative stress in the slim1 mutants, and slim1 alleles were impaired in both thiol accumulation and sulfate accumulation. We further found enhanced arsenic accumulation in roots of slim1 mutants. Transcriptome analyses indicate an important role for SLIM1 in arsenic-induced tolerance mechanisms. The present study identifies the SLIM1 transcription factor as an essential component in arsenic tolerance and arsenic-induced gene expression. Our results suggest that the severe arsenic sensitivity of the slim1 mutants is caused by altered redox status.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Jobe, Timothy O. UNSPECIFIED UNSPECIFIED UNSPECIFIED Yu, Qi UNSPECIFIED UNSPECIFIED UNSPECIFIED Hauser, Felix UNSPECIFIED UNSPECIFIED UNSPECIFIED Xie, Qingqing UNSPECIFIED UNSPECIFIED UNSPECIFIED Meng, Yuan UNSPECIFIED UNSPECIFIED UNSPECIFIED Maassen, Tim UNSPECIFIED UNSPECIFIED UNSPECIFIED Kopriva, Stanislav UNSPECIFIED orcid.org/0000-0002-7416-6551 UNSPECIFIED Schroeder, Julian I. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-589331
DOI:	10.1002/1873-3468.14096
Journal or Publication Title:	FEBS Lett.
Volume:	595
Number:	12
Page Range:	S. 1696 - 1708
Date:	2021
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1873-3468
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GLUTATHIONE; PHOSPHATE; CADMIUM; ACCUMULATION; TOLERANCE; TRANSPORT; TOXICITY; MECHANISMS; REGULATOR; MUTANTS Multiple languages Biochemistry & Molecular Biology; Biophysics; Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58933