Universität zu Köln

Abou Fayad, Antoine G., Haraoui, Louis-Patrick ORCID: 0000-0002-3713-7866, Sleiman, Ahmad, Jaafar, Mohamad, Zorgani, Abdulaziz, Matar, Ghassan M. and Higgins, Paul G. ORCID: 0000-0001-8677-9454 (2021). Diversity of Sequence Types and Impact of Fitness Cost among Carbapenem-Resistant Acinetobacter baumannii Isolates from Tripoli, Libya. Antimicrob. Agents Chemother., 65 (8). WASHINGTON: AMER SOC MICROBIOLOGY. ISSN 1098-6596

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Abstract

We investigated the molecular epidemiology of 21 carbapenem-resistant Acinetobacter baumannii isolates from Libya and assessed their relative fitness. Core genome multilocus sequence typing (MLST) revealed five interhospital transmission clusters. Three clusters were associated with the international clones (IC) IC1, IC2, and IC7. Carbapenem-resistance was associated with bla(OXA-23), bla(GES-11), or bla(NDM-1). Compared to that of A. baumannii DSM 30008, the doubling time was similar over 10 h, but after 16 h, half the isolates grew to higher densities, suggesting a fitness advantage.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Abou Fayad, Antoine G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Haraoui, Louis-Patrick UNSPECIFIED orcid.org/0000-0002-3713-7866 UNSPECIFIED Sleiman, Ahmad UNSPECIFIED UNSPECIFIED UNSPECIFIED Jaafar, Mohamad UNSPECIFIED UNSPECIFIED UNSPECIFIED Zorgani, Abdulaziz UNSPECIFIED UNSPECIFIED UNSPECIFIED Matar, Ghassan M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Higgins, Paul G. UNSPECIFIED orcid.org/0000-0001-8677-9454 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-589792
DOI:	10.1128/AAC.00277-21
Journal or Publication Title:	Antimicrob. Agents Chemother.
Volume:	65
Number:	8
Date:	2021
Publisher:	AMER SOC MICROBIOLOGY
Place of Publication:	WASHINGTON
ISSN:	1098-6596
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language UNITED-STATES; IRAQ Multiple languages Microbiology; Pharmacology & Pharmacy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58979