Universität zu Köln

Macherey, S., Meertens, M. M., Adler, C., Braumann, S., Heyne, S., Tichelbaecker, T., Niessen, F. S., Christ, H., Ahrens, I, Baer, F. M., Eberhardt, F., Horlitz, M., Meissner, A., Sinning, J. M., Baldus, S. and Lee, S. (2021). Impact of respiratory infectious epidemics on STEMI incidence and care. Sci Rep, 11 (1). BERLIN: NATURE PORTFOLIO. ISSN 2045-2322

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Abstract

The effect of respiratory infectious diseases on STEMI incidence, but also STEMI care is not well understood. The Influenza 2017/2018 epidemic and the COVID-19 pandemic were chosen as observational periods to investigate the effect of respiratory virus diseases on these outcomes in a metropolitan area with an established STEMI network. We analyzed data on incidence and care during the COVID-19 pandemic, Influenza 2017/2018 epidemic and corresponding seasonal control periods. Three comparisons were performed: (1) COVID-19 pandemic group versus pandemic control group, (2) COVID-19 pandemic group versus Influenza 2017/2018 epidemic group and (3) Influenza 2017/2018 epidemic group versus epidemic control group. We used Student's t-test, Fisher's exact test and Chi square test for statistical analysis. 1455 patients were eligible. The daily STEMI incidence was 1.49 during the COVID-19 pandemic, 1.40 for the pandemic season control period, 1.22 during the Influenza 2017/2018 epidemic and 1.28 during the epidemic season control group. Median symptom-to-contact time was 180 min during the COVID-19 pandemic. In the pandemic season control group it was 90 min (p = 0.183), and in the Influenza 2017/2018 cohort it was 90 min, too (p = 0.216). Interval in the epidemic control group was 79 min (p = 0.733). The COVID-19 group had a door-to-balloon time of 49 min, corresponding intervals were 39 min for the pandemic season group (p = 0.038), 37 min for the Influenza 2017/2018 group (p = 0.421), and 38 min for the epidemic season control group (p = 0.429). In-hospital mortality was 6.1% for the COVID-19 group, 5.9% for the Influenza 2017/2018 group (p = 1.0), 11% and 11.2% for the season control groups. The respiratory virus diseases neither resulted in an overall treatment delay, nor did they cause an increase in STEMI mortality or incidence. The registry analysis demonstrated a prolonged door-to-balloon time during the COVID-19 pandemic.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Macherey, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Meertens, M. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Adler, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Braumann, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Heyne, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tichelbaecker, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Niessen, F. S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Christ, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ahrens, I UNSPECIFIED UNSPECIFIED UNSPECIFIED Baer, F. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Eberhardt, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Horlitz, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Meissner, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sinning, J. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Baldus, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lee, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-589980
DOI:	10.1038/s41598-021-02480-z
Journal or Publication Title:	Sci Rep
Volume:	11
Number:	1
Date:	2021
Publisher:	NATURE PORTFOLIO
Place of Publication:	BERLIN
ISSN:	2045-2322
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MYOCARDIAL-INFARCTION; GUIDELINES; MANAGEMENT Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/58998