Universität zu Köln

Jais, Alexander and Bruning, Jens C. (2022). Arcuate Nucleus-Dependent Regulation of Metabolism-Pathways to Obesity and Diabetes Mellitus. Endocr. Rev., 43 (2). S. 314 - 329. WASHINGTON: ENDOCRINE SOC. ISSN 1945-7189

Full text not available from this repository.

Abstract

The central nervous system (CNS) receives information from afferent neurons, circulating hormones, and absorbed nutrients and integrates this information to orchestrate the actions of the neuroendocrine and autonomic nervous systems in maintaining systemic metabolic homeostasis. Particularly the arcuate nucleus of the hypothalamus (ARC) is of pivotal importance for primary sensing of adiposity signals, such as leptin and insulin, and circulating nutrients, such as glucose. Importantly, energy state-sensing neurons in the ARC not only regulate feeding but at the same time control multiple physiological functions, such as glucose homeostasis, blood pressure, and innate immune responses. These findings have defined them as master regulators, which adapt integrative physiology to the energy state of the organism. The disruption of this fine-tuned control leads to an imbalance between energy intake and expenditure as well as deregulation of peripheral metabolism. Improving our understanding of the cellular, molecular, and functional basis of this regulatory principle in the CNS could set the stage for developing novel therapeutic strategies for the treatment of obesity and metabolic syndrome. In this review, we summarize novel insights with a particular emphasis on ARC neurocircuitries regulating food intake and glucose homeostasis and sensing factors that inform the brain of the organismal energy status.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Jais, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruning, Jens C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-590538
DOI:	10.1210/endrev/bnab025
Journal or Publication Title:	Endocr. Rev.
Volume:	43
Number:	2
Page Range:	S. 314 - 329
Date:	2022
Publisher:	ENDOCRINE SOC
Place of Publication:	WASHINGTON
ISSN:	1945-7189
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BODY-MASS INDEX; AGOUTI-RELATED PEPTIDE; PLASMA GHRELIN LEVELS; POMC NEURONS; AGRP NEURONS; FOOD-INTAKE; PROOPIOMELANOCORTIN NEURONS; EXPRESSING NEURONS; INSULIN SENSITIVITY; NEURAL CIRCUIT Multiple languages Endocrinology & Metabolism Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59053