Universität zu Köln

Zoellner, Anna, Herfarth, Klaus, Herold, Michael, Klapper, Wolfram, Skoetz, Nicole and Hiddemann, Wolfgang (2021). Follicular Lymphoma-Diagnosis, Treatment, and Follow-Up. Dtsch. Arztebl. Int., 118 (18). S. 320 - 331. COLOGNE: DEUTSCHER AERZTE-VERLAG GMBH. ISSN 1866-0452

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Abstract

Background: Follicular lymphoma (FL) occurs predominantly at advanced age, with an annual incidence of 3-5 cases per 100 000 inhabitants in Western countries. The clinical course is heterogeneous. Methods: For this new guideline, systematic literature searches were conducted in medical databases (MEDLINE. PubMed Central) (up to November 2017) and in the Guidelines International Network (G-I-N). and recent publications were added. Results: The results of 21 systematic reviews with meta-analyses. 75 randomized controlled trials, and 58 prospective and retrospective studies were evaluated. Lymph-node biopsy is necessary for initial diagnosis of FL. CT scanning of the neck, thorax, and abdomen should be performed to assess how far the disease has spread, together with bone marrow biopsy and, if required, PET/CT. In early FL (stages I and II; 10-15 %), potentially curative radiotherapy combined with an antiCD 20 antibody is recommended. In advanced disease (stages III and IV), watchful waiting is indicated for patients who have no clinical symptoms and a low tumor burden. Patients with clinical symptoms and/or high tumor burden should receive chemotherapy in combination with an anti-CD 20 antibody, followed by 2 years' maintenance treatment with an anti-CD 20 antibody. Conclusion: Given the good long-term prognosis of FL, the treatment must be chosen with care and thorough follow-up is necessary to ensure detection of late sequelae such as second malignancies or organ damage.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zoellner, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Herfarth, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Herold, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Klapper, Wolfram UNSPECIFIED UNSPECIFIED UNSPECIFIED Skoetz, Nicole UNSPECIFIED UNSPECIFIED UNSPECIFIED Hiddemann, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-590715
DOI:	10.3238/arztebl.m2021.0022
Journal or Publication Title:	Dtsch. Arztebl. Int.
Volume:	118
Number:	18
Page Range:	S. 320 - 331
Date:	2021
Publisher:	DEUTSCHER AERZTE-VERLAG GMBH
Place of Publication:	COLOGNE
ISSN:	1866-0452
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LOW-GRADE LYMPHOMA; POSITRON-EMISSION-TOMOGRAPHY; NON-HODGKIN-LYMPHOMA; RITUXIMAB MAINTENANCE; INDOLENT LYMPHOMA; ADVANCED-STAGE; PHASE-III; RADIOTHERAPY; CHEMOTHERAPY; INTERFERON Multiple languages Medicine, General & Internal Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59071