Universität zu Köln

Wunsch, Stefanie, Zurl, Christoph ORCID: 0000-0003-0623-0360, Strohmaier, Heimo, Meinitzer, Andreas, Rabensteiner, Jasmin, Posch, Wilfried ORCID: 0000-0001-8955-7654, Lass-Floerl, Cornelia, Cornely, Oliver, Pregartner, Gudrun, Koenig, Elisabeth, Feierl, Gebhard, Hoenigl, Martin ORCID: 0000-0002-1653-2824, Prattes, Juergen ORCID: 0000-0001-5751-9311, Zollner-Schwetz, Ines, Valentin, Thomas and Krause, Robert (2021). Longitudinal Evaluation of Plasma Cytokine Levels in Patients with Invasive Candidiasis. J. Fungi, 7 (2). BASEL: MDPI. ISSN 2309-608X

Full text not available from this repository.

Abstract

Interleukin (IL) 17A plays a decisive role in anti-Candida host defense. Previous data demonstrated significantly increased IL-17A values in candidemic patients. We evaluated levels and time courses of IL-17A, and other cytokines suggested to be involved in Candida-specific immunity (IL-6, IL-8, IL-10, IL-17F, IL-22, IL-23, interferon-gamma, tumor necrosis factor-alpha, Pentraxin-related protein 3, transforming growth factor-beta) in patients with invasive candidiasis (IC) compared to bacteremic patients (Staphylococcus aureus, Escherichia coli) and healthy controls (from previous 4 days up to day 14 relative to the index culture (-4; 14)). IL-17A levels were significantly elevated in all groups compared to healthy controls. In IC, the highest IL-17A values were measured around the date of index sampling (-1; 2), compared to significantly lower levels prior and after sampling the index culture. Candidemic patients showed significantly higher IL-17A values compared to IC other than candidemia at time interval (-1; 2) and (3; 7). No significant differences in IL-17A levels could be observed for IC compared to bacteremic patients. Candidemic patients had higher IL-8, IL-10, IL-22, IFN-gamma, PTX3 and TNF-alpha values compared to non-candidemic. Based on the limited discriminating competence between candidemia and bacteremia, IL-17A has to be considered a biomarker for blood stream infection rather than invasive Candida infection.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wunsch, Stefanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Zurl, Christoph UNSPECIFIED orcid.org/0000-0003-0623-0360 UNSPECIFIED Strohmaier, Heimo UNSPECIFIED UNSPECIFIED UNSPECIFIED Meinitzer, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Rabensteiner, Jasmin UNSPECIFIED UNSPECIFIED UNSPECIFIED Posch, Wilfried UNSPECIFIED orcid.org/0000-0001-8955-7654 UNSPECIFIED Lass-Floerl, Cornelia UNSPECIFIED UNSPECIFIED UNSPECIFIED Cornely, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Pregartner, Gudrun UNSPECIFIED UNSPECIFIED UNSPECIFIED Koenig, Elisabeth UNSPECIFIED UNSPECIFIED UNSPECIFIED Feierl, Gebhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoenigl, Martin UNSPECIFIED orcid.org/0000-0002-1653-2824 UNSPECIFIED Prattes, Juergen UNSPECIFIED orcid.org/0000-0001-5751-9311 UNSPECIFIED Zollner-Schwetz, Ines UNSPECIFIED UNSPECIFIED UNSPECIFIED Valentin, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Krause, Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-590823
DOI:	10.3390/jof7020101
Journal or Publication Title:	J. Fungi
Volume:	7
Number:	2
Date:	2021
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2309-608X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HOST-DEFENSE; CANDIDEMIA; DIAGNOSIS; IL-17; INFECTIONS; MORTALITY; IMMUNITY; ALBICANS; OUTCOMES; THERAPY Multiple languages Microbiology; Mycology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59082