Universität zu Köln

Weiss, Sarah, Hallmann, Steffen, Koch, Stefan, Eidt, Sebastian, Stoehr, Robert, Veltrup, Elke, Roggisch, Jenny, Wirtz, Ralph M. and Ecke, Thorsten H. (2021). Identifying the Molecular Mechanisms Contributing to Progression, Metastasis, and Death in Low-grade Non-muscle-invasive Bladder Cancer: A Case Report. Eur. Urol. Open Sci., 27. S. 29 - 33. AMSTERDAM: ELSEVIER. ISSN 2666-1683

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Abstract

Transitional cell carcinoma of the bladder is a common malignancy with an estimated 549 393 new cases occurring in 2018 alone. Both non-muscle-invasive bladder cancer (NMIBC) and muscle-invasive bladder cancer (MIBC) show high recurrence and progression rates, and therefore impose a great burden on patients and health care systems. Current risk stratification and therapy strategies are predominantly based on clinical and histopathological findings for tumor stage and grade. The chemoresistance and metastasis of low-grade tumors suggest an incomplete understanding of disease mechanisms, despite numerous studies on differentiating molecular subtypes of bladder cancer to identify tumor drivers and potential therapeutic targets. We present a highly unusual course for a low-grade bladder tumor leading to metastasis and death, for which we used postmortem histopathological and molecular analyses to evaluate targetable alterations in key signaling pathways driving the underlying tumor biology. (C) 2021 The Authors. Published by Elsevier B.V. on behalf of European Association of Urology.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Weiss, Sarah UNSPECIFIED UNSPECIFIED UNSPECIFIED Hallmann, Steffen UNSPECIFIED UNSPECIFIED UNSPECIFIED Koch, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Eidt, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Stoehr, Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED Veltrup, Elke UNSPECIFIED UNSPECIFIED UNSPECIFIED Roggisch, Jenny UNSPECIFIED UNSPECIFIED UNSPECIFIED Wirtz, Ralph M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ecke, Thorsten H. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-590918
DOI:	10.1016/j.euros.2021.02.006
Journal or Publication Title:	Eur. Urol. Open Sci.
Volume:	27
Page Range:	S. 29 - 33
Date:	2021
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	2666-1683
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MESSENGER-RNA; STAGE; SUBTYPES Multiple languages Urology & Nephrology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59091