Universität zu Köln

Seger, Aline D., Farrher, Ezequiel, Doppler, Christopher E. J. ORCID: 0000-0002-1341-0389, Gogishvili, Ana, Worthoff, Wieland A., Filss, Christian P., Barbe, Michael T. ORCID: 0000-0003-1149-8054, Holtbernd, Florian, Shah, N. Jon, Fink, Gereon R. ORCID: 0000-0002-8230-1856 and Sommerauer, Michael (2021). Putaminal y-Aminobutyric Acid Modulates Motor Response to Dopaminergic Therapy in Parkinson's Disease. Mov. Disord., 36 (9). S. 2187 - 2193. HOBOKEN: WILEY. ISSN 1531-8257

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Abstract

Background Motor response to dopaminergic therapy is a characteristic of patients with Parkinson's disease (PD). Whether nondopaminergic neurotransmitters contribute to treatment response is uncertain. Objectives The aim of this study is to determine whether putaminal y-aminobutyric acid (GABA) levels are associated with dopaminergic motor response. Methods We assessed putaminal GABA levels in 19 PD patients and 13 healthy controls (HCs) utilizing ultra-high field proton magnetic resonance spectroscopy. Motor performance was evaluated using the Movement Disorder Society-Unified Parkinson's Disease Rating Scale, Part III, in the ON and OFF states. Statistical analysis comprised group comparisons, correlation analysis, and multiple linear regression. Results In PD, GABA levels were significantly higher compared to HCs (1.50 +/- 0.26 mM vs. 1.26 +/- 0.31 mM, P = 0.022). Furthermore, GABA levels were independent predictors of absolute and relative dopaminergic treatment response. Conclusions Our findings indicate that elevated putaminal GABA levels are associated with worse dopaminergic response in PD, emphasizing the essential role of nondopaminergic neurotransmitters in motor response. (c) 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Seger, Aline D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Farrher, Ezequiel UNSPECIFIED UNSPECIFIED UNSPECIFIED Doppler, Christopher E. J. UNSPECIFIED orcid.org/0000-0002-1341-0389 UNSPECIFIED Gogishvili, Ana UNSPECIFIED UNSPECIFIED UNSPECIFIED Worthoff, Wieland A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Filss, Christian P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Barbe, Michael T. UNSPECIFIED orcid.org/0000-0003-1149-8054 UNSPECIFIED Holtbernd, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Shah, N. Jon UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Sommerauer, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-590947
DOI:	10.1002/mds.28674
Journal or Publication Title:	Mov. Disord.
Volume:	36
Number:	9
Page Range:	S. 2187 - 2193
Date:	2021
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1531-8257
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LEVODOPA RESPONSE Multiple languages Clinical Neurology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59094