Universität zu Köln

Neumaier, Felix ORCID: 0000-0002-6376-6391, Stoppe, Christian, Veldeman, Michael, Weiss, Miriam, Simon, Tim, Hoellig, Anke, Marx, Gernot, Clusmann, Hans and Albanna, Walid (2021). Circulatory dipeptidyl peptidase 3 (cDPP3) is a potential biomarker for early detection of secondary brain injury after aneurysmal subarachnoid hemorrhage. J. Neurol. Sci., 422. AMSTERDAM: ELSEVIER. ISSN 1878-5883

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Abstract

Introduction: Delayed cerebral ischemia (DCI) is a common complication after aneurysmal subarachnoid hemorrhage (aSAH) that can culminate in secondary brain damage. Although it remains one of the main preventable causes of aSAH-related morbidity, there is still a lack of prognostic criteria for identification of patients at risk of developing DCI. Because elevated circulatory levels of the enzyme dipeptidyl peptidase 3 (cDPP3) were recently identified as a potential biomarker for outcome prediction in critically ill patients, we evaluated the time-course of changes in cDPP3 levels after aSAH. Materials and methods: cDPP3 levels were quantified in serum obtained from 96 confirmed aSAH patients during the early (EP: d(1-4)), critical (CP: d(5-8), d(9-12), d(13-15)) and late (LP: d(16-21)) phase after aSAH onset. Associations between cDPP3 levels and demographic or clinical parameters were evaluated. The relations between cDPP3 levels and DCI, DCI-related infarctions and long-term clinical outcomes were examined by receiver operating characteristics (ROC) curve analysis and multivariate logistic regression. Results: Significantly higher cDPP3 levels during CP (d(5-8), d(9-12), d(13-15)) were observed in patients with poor clinical (p < 0.001 top = 0.033) or radiological (p = 0.012 top = 0.039) status on admission, DCI (p < 0.001 top = 0.001), DCI-related infarctions (p = 0.002 top = 0.007), and poorer long-term outcome (p = 0.007 top = 0.019). ROC curve analysis indicated that higher cDPP3 levels on d(5-8) are predictive for a poor clinical outcome (area under the curve = 0.677, p = 0.007). In multivariate analysis, there was an independent association between cDPP3 levels on d(5-8) and development of DCI-related infarctions (p = 0.038). Conclusion: Our results provide first evidence that cDPP3 could serve as a promising biomarker for early diagnosis of DCI-related infarctions in poor grade aSAH patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Neumaier, Felix UNSPECIFIED orcid.org/0000-0002-6376-6391 UNSPECIFIED Stoppe, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Veldeman, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Weiss, Miriam UNSPECIFIED UNSPECIFIED UNSPECIFIED Simon, Tim UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoellig, Anke UNSPECIFIED UNSPECIFIED UNSPECIFIED Marx, Gernot UNSPECIFIED UNSPECIFIED UNSPECIFIED Clusmann, Hans UNSPECIFIED UNSPECIFIED UNSPECIFIED Albanna, Walid UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-590964
DOI:	10.1016/j.jns.2021.117333
Journal or Publication Title:	J. Neurol. Sci.
Volume:	422
Date:	2021
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	1878-5883
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Clinical Neurology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59096