Universität zu Köln

Rokohl, Alexander C., Trester, Marc, Naderi, Parsa, Loreck, Niklas, Zwingelberg, Sarah, Bucher, Franziska, Pine, Keith R. and Heindl, Ludwig M. (2021). Dry anophthalmic socket syndrome - morphological alterations in meibomian glands. Eye, 35 (12). S. 3358 - 3367. LONDON: SPRINGERNATURE. ISSN 1476-5454

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Abstract

Purpose To evaluate morphological alterations of meibomian glands (MGs) in the dry anophthalmic socket syndrome (DASS). Methods Fifteen unilateral anophthalmic patients wearing cryolite glass prosthetic eyes were enrolled. All patients with clinical blepharitis or other significant eyelid abnormalities were excluded. In vivo laser scanning confocal microscopy (LSCM) of the MGs in the lower eyelids both on the anophthalmic side and the healthy fellow eye was performed to quantify acinar unit density, acinar unit diameter, acinar unit area, meibum secretion reflectivity, the inhomogeneous appearance of the glandular interstice, and inhomogeneous appearance of the acinar walls. Results The lower eyelids of the anophthalmic sockets revealed a significant reduction of the acinar unit density (p = 0.003) as well as a significantly more inhomogeneous appearance of the periglandular interstices (p = 0.018) and the acinar unit walls (p = 0.015) than the healthy fellow eyelid. However, there were no significant differences regarding the acinar unit diameter, acinar unit area, and meibum secretion reflectivity of the MGs on the anophthalmic side compared to the healthy fellow eyelid (p >= 0.05, respectively). Conclusions The eyelids of anophthalmic sockets without clinical blepharitis demonstrate a reduced density of MG acinar units and a more inhomogeneous appearance of the periglandular interstices and the acinar unit walls. This can cause meibomian gland dysfunction contributing to DASS and suggests early treatment of these symptomatic patients, even in the clinical absence of any blepharitis signs.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rokohl, Alexander C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Trester, Marc UNSPECIFIED UNSPECIFIED UNSPECIFIED Naderi, Parsa UNSPECIFIED UNSPECIFIED UNSPECIFIED Loreck, Niklas UNSPECIFIED UNSPECIFIED UNSPECIFIED Zwingelberg, Sarah UNSPECIFIED UNSPECIFIED UNSPECIFIED Bucher, Franziska UNSPECIFIED UNSPECIFIED UNSPECIFIED Pine, Keith R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Heindl, Ludwig M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-591117
DOI:	10.1038/s41433-021-01426-z
Journal or Publication Title:	Eye
Volume:	35
Number:	12
Page Range:	S. 3358 - 3367
Date:	2021
Publisher:	SPRINGERNATURE
Place of Publication:	LONDON
ISSN:	1476-5454
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59111