Change in the ophthalmoscopical optic disc size and shape in a 10-year follow-up: the Beijing Eye Study 2001-2011

Jonas, Jost B., Zhang, Qi, Xu, Liang, Wei, Wen Bin, Jonas, Rahul A. and Wang, Ya Xing . Change in the ophthalmoscopical optic disc size and shape in a 10-year follow-up: the Beijing Eye Study 2001-2011. Br. J. Ophthalmol.. LONDON: BMJ PUBLISHING GROUP. ISSN 1468-2079

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DOI:10.1136/bjophthalmol-2021-319632

Abstract

Background To assess prevalence and associated factors of changes in the ophthalmoscopic optic disc size and shape. Methods The case-control study included all highly myopic eyes (myopic refractive error <=-6.0 diopters) and a randomly selected group of non-highly myopic eyes, examined in the population-based Beijing Eye Study 2001 and 2011. Results The study included 89 highly myopic eyes (age:65.0 +/- 9.8 years) and 86 non-highly myopic eyes. Reduction in ophthalmoscopic disc size (prevalence, high myopia: 30 (33.7%) eyes; non-high myopia: 7 (8.1%) eyes) was associated with non-circular gamma zone enlargement (OR: 19.4; 95% CI: 6.7 to 56.6; p<0.001) and disc-fovea line elongation (OR: 2.80;95% CI: 1.12 to 6.98; p=0.03). Disc size reduction was correlated with a disc diameter shortening in direction of the widest gamma zone enlargement (correlation coefficient r=34; p=0.01). The perpendicular disc diameter remained mostly unchanged, resulting in an ovalisation of the ophthalmoscopic disc shape. Enlargement of the ophthalmoscopic disc size (prevalence, high myopia: 22 (24.7%) eyes; non-high myopia: 4 (4.7%) eyes) was associated with circular gamma zone enlargement (4.99; 95% CI: 1.95 to 12.8; p=0.001) and high myopia (OR: 4.29; 95% CI: 1.34 to 13.8; p=0.01). Conclusions Myopic axial elongation may lead first to a Bruch's membrane (BM) opening (BMO) shift into the foveal direction leading to BM overhanging into the nasal intrapapillary compartment, development and enlargement of gamma zone at the temporal disc side, reduction in the ophthalmoscopically visible disc area and ovalisation of the ophthalmoscopic disc shape. In a second step, an axial elongation-associated BMO enlargement may lead to a circular gamma zone increase and, due to the retraction of BM at the nasal disc border, to an enlargement of the ophthalmoscopically visible optic disc.

Item Type:

Journal Article

Creators:

Creators	Email	ORCID	ORCID Put Code
Jonas, Jost B.	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED
Zhang, Qi	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED
Xu, Liang	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED
Wei, Wen Bin	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED
Jonas, Rahul A.	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED
Wang, Ya Xing	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED