Universität zu Köln

Olum, Ronald ORCID: 0000-0003-1289-0111, Osaigbovo, Iriagbonse Iyabo, Baluku, Joseph Baruch ORCID: 0000-0002-5852-9674, Stemler, Jannik ORCID: 0000-0001-9152-2469, Kwizera, Richard ORCID: 0000-0002-5270-3539 and Bongomin, Felix ORCID: 0000-0003-4515-8517 (2021). Mapping of Chronic Pulmonary Aspergillosis in Africa. J. Fungi, 7 (10). BASEL: MDPI. ISSN 2309-608X

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Abstract

Africa has a high burden of tuberculosis, which is the most important risk factor for chronic pulmonary aspergillosis (CPA). Our goal was to systematically evaluate the burden of CPA in Africa and map it by country. We conducted an extensive literature search for publications on CPA in Africa using the online databases. We reviewed a total of 41 studies published between 1976 and 2021, including a total of 1247 CPA cases from 14 African countries. Most of the cases came from Morocco (n = 764, 62.3%), followed by South Africa (n = 122, 9.9%) and Senegal (n = 99, 8.1%). Seventeen (41.5%) studies were retrospective, 12 (29.3%) were case reports, 5 case series (12.2%), 5 prospective cohorts, and 2 cross-sectional studies. The majority of the cases (67.1%, n = 645) were diagnosed in men, with a median age of 41 years (interquartile range: 36-45). Active/previously treated pulmonary tuberculosis (n = 764, 61.3%), human immunodeficiency virus infection (n = 29, 2.3%), diabetes mellitus (n = 19, 1.5%), and chronic obstructive pulmonary disease (n = 10, 0.8%) were the common co-morbidities. Haemoptysis was the most frequent presenting symptom, reported in up to 717 (57%) cases. Smoking (n = 69, 5.5%), recurrent lung infections (n = 41, 3%) and bronchorrhea (n = 33, 3%) were noted. This study confirms that CPA is common in Africa, with pulmonary tuberculosis being the most important risk factor.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Olum, Ronald UNSPECIFIED orcid.org/0000-0003-1289-0111 UNSPECIFIED Osaigbovo, Iriagbonse Iyabo UNSPECIFIED UNSPECIFIED UNSPECIFIED Baluku, Joseph Baruch UNSPECIFIED orcid.org/0000-0002-5852-9674 UNSPECIFIED Stemler, Jannik UNSPECIFIED orcid.org/0000-0001-9152-2469 UNSPECIFIED Kwizera, Richard UNSPECIFIED orcid.org/0000-0002-5270-3539 UNSPECIFIED Bongomin, Felix UNSPECIFIED orcid.org/0000-0003-4515-8517 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-591669
DOI:	10.3390/jof7100790
Journal or Publication Title:	J. Fungi
Volume:	7
Number:	10
Date:	2021
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2309-608X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SURGICAL-TREATMENT; FIBROSING PULMONARY; CHRONIC CAVITARY; DESTROYED LUNG; GLOBAL BURDEN; MANAGEMENT; HEMOPTYSIS; DIAGNOSIS; TUBERCULOSIS; EXPERIENCE Multiple languages Microbiology; Mycology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59166