Universität zu Köln

Koch, Vitali, Hokamp, Nils Grosse, Albrecht, Moritz H., Gruenewald, Leon D., Yel, Ibrahim, Borggrefe, Jan ORCID: 0000-0003-2908-7560, Wesarg, Stefan, Eichler, Katrin, Burck, Iris, Gruber-Rouh, Tatjana, Lenga, Lukas, Vogl, Thomas J., Martin, Simon S., Wichmann, Julian L., Hammerstingl, Renate M., Alizadeh, Leona S., Mader, Christoph, Huizinga, Nicole A., D'Angelo, Tommaso ORCID: 0000-0003-0004-6378, Ascenti, Giorgio, Mazziotti, Silvio and Booz, Christian (2021). Accuracy and precision of volumetric bone mineral density assessment using dual-source dual-energy versus quantitative CT: a phantom study. Eur. Radiol. Exp., 5 (1). LONDON: SPRINGERNATURE. ISSN 2509-9280

Full text not available from this repository.

Abstract

Background Dual-source dual-energy computed tomography (DECT) offers the potential for opportunistic osteoporosis screening by enabling phantomless bone mineral density (BMD) quantification. This study sought to assess the accuracy and precision of volumetric BMD measurement using dual-source DECT in comparison to quantitative CT (QCT). Methods A validated spine phantom consisting of three lumbar vertebra equivalents with 50 (L1), 100 (L2), and 200 mg/cm(3) (L3) calcium hydroxyapatite (HA) concentrations was scanned employing third-generation dual-source DECT and QCT. While BMD assessment based on QCT required an additional standardised bone density calibration phantom, the DECT technique operated by using a dedicated postprocessing software based on material decomposition without requiring calibration phantoms. Accuracy and precision of both modalities were compared by calculating measurement errors. In addition, correlation and agreement analyses were performed using Pearson correlation, linear regression, and Bland-Altman plots. Results DECT-derived BMD values differed significantly from those obtained by QCT (p < 0.001) and were found to be closer to true HA concentrations. Relative measurement errors were significantly smaller for DECT in comparison to QCT (L1, 0.94% versus 9.68%; L2, 0.28% versus 5.74%; L3, 0.24% versus 3.67%, respectively). DECT demonstrated better BMD measurement repeatability compared to QCT (coefficient of variance < 4.29% for DECT, < 6.74% for QCT). Both methods correlated well to each other (r = 0.9993; 95% confidence interval 0.9984-0.9997; p < 0.001) and revealed substantial agreement in Bland-Altman plots. Conclusions Phantomless dual-source DECT-based BMD assessment of lumbar vertebra equivalents using material decomposition showed higher diagnostic accuracy compared to QCT.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Koch, Vitali UNSPECIFIED UNSPECIFIED UNSPECIFIED Hokamp, Nils Grosse UNSPECIFIED UNSPECIFIED UNSPECIFIED Albrecht, Moritz H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gruenewald, Leon D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Yel, Ibrahim UNSPECIFIED UNSPECIFIED UNSPECIFIED Borggrefe, Jan UNSPECIFIED orcid.org/0000-0003-2908-7560 UNSPECIFIED Wesarg, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Eichler, Katrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Burck, Iris UNSPECIFIED UNSPECIFIED UNSPECIFIED Gruber-Rouh, Tatjana UNSPECIFIED UNSPECIFIED UNSPECIFIED Lenga, Lukas UNSPECIFIED UNSPECIFIED UNSPECIFIED Vogl, Thomas J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Martin, Simon S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wichmann, Julian L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hammerstingl, Renate M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Alizadeh, Leona S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mader, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Huizinga, Nicole A. UNSPECIFIED UNSPECIFIED UNSPECIFIED D'Angelo, Tommaso UNSPECIFIED orcid.org/0000-0003-0004-6378 UNSPECIFIED Ascenti, Giorgio UNSPECIFIED UNSPECIFIED UNSPECIFIED Mazziotti, Silvio UNSPECIFIED UNSPECIFIED UNSPECIFIED Booz, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-591714
DOI:	10.1186/s41747-021-00241-1
Journal or Publication Title:	Eur. Radiol. Exp.
Volume:	5
Number:	1
Date:	2021
Publisher:	SPRINGERNATURE
Place of Publication:	LONDON
ISSN:	2509-9280
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language X-RAY ABSORPTIOMETRY; COMPUTED-TOMOGRAPHY; TRABECULAR BONE; OSTEOPOROSIS; MARROW; ERRORS; VALIDATION; FRACTURES; DESIGN; DXA Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59171