Universität zu Köln

Ophey, Anja ORCID: 0000-0001-5858-7762, Krohm, Fabian ORCID: 0000-0001-5411-6007, Kalbe, Elke ORCID: 0000-0001-8603-2545, Greuel, Andrea ORCID: 0000-0002-0001-9225, Drzezga, Alexander ORCID: 0000-0001-6018-716X, Tittgemeyer, Marc ORCID: 0000-0001-5072-2149, Timmermann, Lars ORCID: 0000-0002-5301-3580, Jessen, Frank ORCID: 0000-0003-1067-2102, Eggers, Carsten and Maier, Franziska ORCID: 0000-0002-9335-9594 (2021). Neural correlates and predictors of subjective cognitive decline in patients with Parkinson's disease. Neurol. Sci., 43. pp. 3153-3163. MILAN: SPRINGER-VERLAG ITALIA SRL. ISSN 1590-3478

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Abstract

Background Subjective cognitive decline (SCD) may occur very early in the course of Parkinson's disease (PD) before the onset of objective cognitive decline. Data on neural correlates and determinants of SCD in PD are rare. Objective The aim of the present study was to identify neural correlates as well as sociodemographic, clinical, and neuropsychological predictors of SCD in patients with PD. Methods We retrospectively analyzed 30 patients with PD without cognitive impairment (23% female, 66.90 +/- 7.20 years, UPDRS-III: 19.83 +/- 9.29), of which n= 12 patients were classified as having no SCD (control group, PD-CG) and n= 18 as having SCD (PD-SCD). Neuropsychological testing and 18-fluoro-2-deoxyglucose positron emission tomography (FDG-PET) were conducted. SCD was assessed using a questionnaire covering multiple cognitive domains. Results SCD subscores differed significantly between PD-CG and PD-SCD and correlated significantly with other scales measuring related concepts. FDG-PET whole-brain voxel-wise regression analysis revealed hypometabolism in middle frontal, middle temporal, and occipital areas, and the angular gyrus as neural correlates of SCD in PD. Next to this hypometabolism, depressive symptoms were an independent significant determinant of SCD in a stepwise regression analysis (adjusted R-2 = 50.3%). Conclusion This study strengthens the hypothesis of SCD being an early manifestation of future cognitive decline in PD and, more generally, early pathological changes in PD. The early identification of the vulnerability for future cognitive decline constitutes the basis for successful prevention and delay of this non-motor symptom.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ophey, Anja UNSPECIFIED orcid.org/0000-0001-5858-7762 UNSPECIFIED Krohm, Fabian UNSPECIFIED orcid.org/0000-0001-5411-6007 UNSPECIFIED Kalbe, Elke UNSPECIFIED orcid.org/0000-0001-8603-2545 UNSPECIFIED Greuel, Andrea UNSPECIFIED orcid.org/0000-0002-0001-9225 UNSPECIFIED Drzezga, Alexander UNSPECIFIED orcid.org/0000-0001-6018-716X UNSPECIFIED Tittgemeyer, Marc UNSPECIFIED orcid.org/0000-0001-5072-2149 UNSPECIFIED Timmermann, Lars UNSPECIFIED orcid.org/0000-0002-5301-3580 UNSPECIFIED Jessen, Frank UNSPECIFIED orcid.org/0000-0003-1067-2102 UNSPECIFIED Eggers, Carsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Maier, Franziska UNSPECIFIED orcid.org/0000-0002-9335-9594 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-591888
DOI:	10.1007/s10072-021-05734-w
Journal or Publication Title:	Neurol. Sci.
Volume:	43
Page Range:	pp. 3153-3163
Date:	2021
Publisher:	SPRINGER-VERLAG ITALIA SRL
Place of Publication:	MILAN
ISSN:	1590-3478
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Sonstiges > Zentrum für Versorgungsforschung Köln
Subjects:	Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language MEMORY COMPLAINTS; OLDER-ADULTS; GLUCOSE-METABOLISM; LEWY BODIES; IMPAIRMENT; DEMENTIA; PREVALENCE; PATTERNS; CRITERIA Multiple languages Clinical Neurology; Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/59188