Universität zu Köln

Dodd, Garron T., Kim, Seung Jae ORCID: 0000-0003-0268-6029, Mequinion, Mathieu, Xirouchaki, Chrysovalantou E., Bruening, Jens C., Andrews, Zane B. ORCID: 0000-0002-9097-7944 and Tiganis, Tony (2021). Insulin signaling in AgRP neurons regulates meal size to limit glucose excursions and insulin resistance. Sci. Adv., 7 (9). WASHINGTON: AMER ASSOC ADVANCEMENT SCIENCE. ISSN 2375-2548

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Abstract

The importance of hypothalamic insulin signaling on feeding and glucose metabolism remains unclear. We report that insulin acts on AgRP neurons to acutely decrease meal size and thereby limit postprandial glucose and insulin excursions. The promotion of insulin signaling in AgRP neurons decreased meal size without altering total caloric intake, whereas the genetic ablation of the insulin receptor had the opposite effect. The promotion of insulin signaling also decreased the intake of sucrose-sweetened water or high-fat food over standard chow, without influencing food-seeking and hedonic behaviors. The ability of heightened insulin signaling to override the hedonistic consumption of highly palatable high-fat food attenuated the development of systemic insulin resistance, without affecting body weight. Our findings define an unprecedented mechanism by which insulin acutely influences glucose metabolism. Approaches that enhance insulin signaling in AgRP neurons may provide a means for altering feeding behavior in a nutrient-dense environment to combat the metabolic syndrome.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Dodd, Garron T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kim, Seung Jae UNSPECIFIED orcid.org/0000-0003-0268-6029 UNSPECIFIED Mequinion, Mathieu UNSPECIFIED UNSPECIFIED UNSPECIFIED Xirouchaki, Chrysovalantou E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruening, Jens C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Andrews, Zane B. UNSPECIFIED orcid.org/0000-0002-9097-7944 UNSPECIFIED Tiganis, Tony UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-591998
DOI:	10.1126/sciadv.abf4100
Journal or Publication Title:	Sci. Adv.
Volume:	7
Number:	9
Date:	2021
Publisher:	AMER ASSOC ADVANCEMENT SCIENCE
Place of Publication:	WASHINGTON
ISSN:	2375-2548
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59199