Universität zu Köln

Khodayari, Hamid ORCID: 0000-0002-5002-7338, Khodayari, Saeed, Ebrahimi, Elmira, Hadjilooei, Farimah, Vesovic, Miko, Mahmoodzadeh, Habibollah, Saric, Tomo, Stuecker, Wilfried, Van Gool, Stefaan, Hescheler, Juergen and Nayernia, Karim (2021). Stem cells-derived natural killer cells for cancer immunotherapy: current protocols, feasibility, and benefits of ex vivo generated natural killer cells in treatment of advanced solid tumors. Cancer Immunol. Immunother., 70 (12). S. 3369 - 3396. NEW YORK: SPRINGER. ISSN 1432-0851

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Abstract

Nowadays, natural killer (NK) cell-based immunotherapy provides a practical therapeutic strategy for patients with advanced solid tumors (STs). This approach is adaptively conducted by the autologous and identical NK cells after in vitro expansion and overnight activation. However, the NK cell-based cancer immunotherapy has been faced with some fundamental and technical limitations. Moreover, the desirable outcomes of the NK cell therapy may not be achieved due to the complex tumor microenvironment by inhibition of intra-tumoral polarization and cytotoxicity of implanted NK cells. Currently, stem cells (SCs) technology provides a powerful opportunity to generate more effective and universal sources of the NK cells. Till now, several strategies have been developed to differentiate types of the pluripotent and adult SCs into the mature NK cells, with both feeder layer-dependent and/or feeder laye-free strategies. Higher cytokine production and intra-tumoral polarization capabilities as well as stronger anti-tumor properties are the main features of these SCs-derived NK cells. The present review article focuses on the principal barriers through the conventional NK cell immunotherapies for patients with advanced STs. It also provides a comprehensive resource of protocols regarding the generation of SCs-derived NK cells in an ex vivo condition.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Khodayari, Hamid UNSPECIFIED orcid.org/0000-0002-5002-7338 UNSPECIFIED Khodayari, Saeed UNSPECIFIED UNSPECIFIED UNSPECIFIED Ebrahimi, Elmira UNSPECIFIED UNSPECIFIED UNSPECIFIED Hadjilooei, Farimah UNSPECIFIED UNSPECIFIED UNSPECIFIED Vesovic, Miko UNSPECIFIED UNSPECIFIED UNSPECIFIED Mahmoodzadeh, Habibollah UNSPECIFIED UNSPECIFIED UNSPECIFIED Saric, Tomo UNSPECIFIED UNSPECIFIED UNSPECIFIED Stuecker, Wilfried UNSPECIFIED UNSPECIFIED UNSPECIFIED Van Gool, Stefaan UNSPECIFIED UNSPECIFIED UNSPECIFIED Hescheler, Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Nayernia, Karim UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-592665
DOI:	10.1007/s00262-021-02975-8
Journal or Publication Title:	Cancer Immunol. Immunother.
Volume:	70
Number:	12
Page Range:	S. 3369 - 3396
Date:	2021
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-0851
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NK CELLS; PHASE-I; ADOPTIVE TRANSFER; IFN-GAMMA; SUPPRESSOR-CELLS; LUNG-CANCER; T-CELLS; MATRIX METALLOPROTEINASES; HEPATOCELLULAR-CARCINOMA; HEMATOPOIETIC STEM Multiple languages Oncology; Immunology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59266