Universität zu Köln

Erices-Leclercq, Melanie, Lubig, Sabine, Foerster, Frank, Forster, Robert, Baldus, Stefan, Rudlowski, Christian and Schroeder, Lars (2022). Prognostic relevance of Ki67 expression in primary male breast cancer: determination of cut-off points by different evaluation methods and statistical examinations. J. Cancer Res. Clin. Oncol., 148 (2). S. 441 - 448. NEW YORK: SPRINGER. ISSN 1432-1335

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Abstract

Purpose 1% of all breast cancer cases occur in men. There are significant differences regarding clinical behaviour and genetic profiles between female (FBC) and male breast cancer (MBC). Parameters for decision-making on treatment and prognosis are derived from FBC. Ki67 has a high value as a prognostic and predictive factor in FBC, but accurate Ki67 cut-off points for MBC are missing. In this study, we aimed to evaluate adequate examination methods and reliable cut-off points for Ki67 to assess the highest prognostic value for patient's overall survival (OS). Methods In this multicentric retrospective study, histological specimens were obtained from 104 male patients who were diagnosed and treated for primary invasive breast cancer. We applied three methods of Ki67 analysis: Tumor average scoring (TA), tumor border scoring (TB) and hot-spot scoring (HS). Calculated Ki67 cut-off points for each method were assessed as a threshold for patients' overall survival (OS). Results Ki67 cut-off points were 13.5 for the TA group, 22.5 for the HS group and 17.5 for the TB group. Only Ki67 TA cut-off calculations demonstrated statistical significance (p = 0.04). Ki67 expression analysis of TA showed that more than 90% of patients with low Ki67 levels (< 13.5) were alive after 5-year follow-up. Conclusion Our findings demonstrate that determination of Ki67 expression in TA is the most reliable to define a cut-off point with high prognostic value. A Ki67 cut-off point of 13.5 shows highest statistical power to define luminal A subgroup and OS.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Erices-Leclercq, Melanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Lubig, Sabine UNSPECIFIED UNSPECIFIED UNSPECIFIED Foerster, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Forster, Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED Baldus, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Rudlowski, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Schroeder, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-592725
DOI:	10.1007/s00432-021-03623-5
Journal or Publication Title:	J. Cancer Res. Clin. Oncol.
Volume:	148
Number:	2
Page Range:	S. 441 - 448
Date:	2022
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-1335
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INTERNATIONAL EXPERT CONSENSUS; PRIMARY THERAPY; INDEX Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59272