Universität zu Köln

Al-Hassan, Leena, Elbadawi, Hana ORCID: 0000-0003-2192-7932, Osman, Einas, Ali, Sara, Elhag, Kamal, Cantillon, Daire ORCID: 0000-0002-2180-373X, Wille, Julia, Seifert, Harald and Higgins, Paul G. ORCID: 0000-0001-8677-9454 (2021). Molecular Epidemiology of Carbapenem-Resistant Acinetobacter baumannii From Khartoum State, Sudan. Front. Microbiol., 12. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1664-302X

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Abstract

Carbapenem resistant Acinetobacter baumannii (CRAb) is an important global pathogen contributing to increased morbidity and mortality in hospitalized patients, due to limited alternative treatment options. Nine international clonal (IC) lineages have been identified in many countries worldwide, however, data still lacks from some parts of the world, particularly in Africa. We hereby present the molecular epidemiology of MDR A. baumannii from four hospitals in Khartoum, Sudan, collected from 2017 to 2018. Forty-two isolates were whole-genome sequenced, and subsequent molecular epidemiology was determined by core genome MLST (cgMLST), and their resistomes identified. All isolates had an array of diverse antibiotic resistance mechanisms conferring resistance to multiple classes of antibiotics. We found a predominance (88%) of IC2 (with the intrinsic OXA-66 and acquired OXA-23), and some with NDM-1. IC2 isolates were sub-divided into 4 STs separated by 5 to 431 allelic differences, and with evidence of seven transmission clusters. Isolates belonging to IC1, IC5, and IC9 were also identified. These data illustrate that MDR IC2 A. baumannii are widely distributed in Khartoum hospitals and are in possession of multiple antibiotic resistance determinants.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Al-Hassan, Leena UNSPECIFIED UNSPECIFIED UNSPECIFIED Elbadawi, Hana UNSPECIFIED orcid.org/0000-0003-2192-7932 UNSPECIFIED Osman, Einas UNSPECIFIED UNSPECIFIED UNSPECIFIED Ali, Sara UNSPECIFIED UNSPECIFIED UNSPECIFIED Elhag, Kamal UNSPECIFIED UNSPECIFIED UNSPECIFIED Cantillon, Daire UNSPECIFIED orcid.org/0000-0002-2180-373X UNSPECIFIED Wille, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Seifert, Harald UNSPECIFIED UNSPECIFIED UNSPECIFIED Higgins, Paul G. UNSPECIFIED orcid.org/0000-0001-8677-9454 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-592979
DOI:	10.3389/fmicb.2021.628736
Journal or Publication Title:	Front. Microbiol.
Volume:	12
Date:	2021
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1664-302X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MULTIPLEX PCR Multiple languages Microbiology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59297