Llamas, Ernesto ORCID: 0000-0001-9262-2402, Torres-Montilla, Salvador, Lee, Hyun Ju, Barja, Maria Victoria, Schlimgen, Elena, Dunken, Nick ORCID: 0000-0003-0563-307X, Wagle, Prerana, Werr, Wolfgang, Zuccaro, Alga ORCID: 0000-0002-8026-0114, Rodriguez-Concepcion, Manuel and Vilchez, David (2021). The intrinsic chaperone network of Arabidopsis stem cells confers protection against proteotoxic stress. Aging Cell, 20 (8). HOBOKEN: WILEY. ISSN 1474-9726

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Abstract

The biological purpose of plant stem cells is to maintain themselves while providing new pools of differentiated cells that form organs and rejuvenate or replace damaged tissues. Protein homeostasis or proteostasis is required for cell function and viability. However, the link between proteostasis and plant stem cell identity remains unknown. In contrast to their differentiated counterparts, we find that root stem cells can prevent the accumulation of aggregated proteins even under proteotoxic stress conditions such as heat stress or proteasome inhibition. Notably, root stem cells exhibit enhanced expression of distinct chaperones that maintain proteome integrity. Particularly, intrinsic high levels of the T-complex protein-1 ring complex/chaperonin containing TCP1 (TRiC/CCT) complex determine stem cell maintenance and their remarkable ability to suppress protein aggregation. Overexpression of CCT8, a key activator of TRiC/CCT assembly, is sufficient to ameliorate protein aggregation in differentiated cells and confer resistance to proteotoxic stress in plants. Taken together, our results indicate that enhanced proteostasis mechanisms in stem cells could be an important requirement for plants to persist under extreme environmental conditions and reach extreme long ages. Thus, proteostasis of stem cells can provide insights to design and breed plants tolerant to environmental challenges caused by the climate change.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Llamas, ErnestoUNSPECIFIEDorcid.org/0000-0001-9262-2402UNSPECIFIED
Torres-Montilla, SalvadorUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lee, Hyun JuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barja, Maria VictoriaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schlimgen, ElenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dunken, NickUNSPECIFIEDorcid.org/0000-0003-0563-307XUNSPECIFIED
Wagle, PreranaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Werr, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zuccaro, AlgaUNSPECIFIEDorcid.org/0000-0002-8026-0114UNSPECIFIED
Rodriguez-Concepcion, ManuelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vilchez, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-593048
DOI: 10.1111/acel.13446
Journal or Publication Title: Aging Cell
Volume: 20
Number: 8
Date: 2021
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1474-9726
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
PROTEIN HOMEOSTASIS; ESSENTIAL GENE; ELEGANS; PLANT; DIFFERENTIATION; DIVISION; RNAIMultiple languages
Cell Biology; Geriatrics & GerontologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/59304

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