Universität zu Köln

Grossek, Anja, Elter, Thomas, Oberste, Max, Wolf, Florian, Joisten, Niklas ORCID: 0000-0002-9947-8746, Hartig, Philipp, Walzik, David, Rosenberger, Friederike, Kiesl, David, Wahl, Patrick ORCID: 0000-0001-8682-5916, Bloch, Wilhelm and Zimmer, Philipp (2021). Feasibility and suitability of a graded exercise test in patients with aggressive hemato-oncological disease. Support. Care Cancer, 29 (8). S. 4859 - 4867. NEW YORK: SPRINGER. ISSN 1433-7339

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Abstract

Purpose Physical activity promises to reduce disease-related symptoms and therapy-related side effects in patients suffering from aggressive lymphoma (L) or acute leukemia (AL). For an efficient training program, determination of patients' physical capacity with a purposive exercise test is crucial. Here, we evaluated the feasibility and suitability of a graded exercise test (GXT) frequently applied in patients suffering from solid tumors by assessing whether patients achieved criteria for maximal exercise testing according to the American College of Sports Medicine (ACSM). Methods The GXT was performed by 51 patients with an aggressive L or AL prior to the start or in the earliest possible phase of high-dose chemotherapy, following a recommended protocol for cancer patients, starting at 20 Watts (W), with an increase of 10 W/min until volitional exhaustion. Subsequently, we investigated whether the following ACSM criteria were fulfilled: (1) failure of heart rate to increase despite increasing workload, (2) post-exercise capillary lactate concentration >= 8.0 mmol L-1, (3) rating of perceived exertion at exercise cessation > 17 on the 6-20 Borg Scale. Results Out of 51 patients, two, six, and 35 participants met the first, second, and third criterion, respectively. No relevant relationships between the completion of the criteria and patients' characteristics (e.g., gender, age) were found. Conclusion Although results of this study suggest a general feasibility of the applied GXT, the ACSM criteria were not met by the majority of the participants. Therefore, this study raises doubts about the suitability of the GXT protocol and the ACSM criteria for this group of patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Grossek, Anja UNSPECIFIED UNSPECIFIED UNSPECIFIED Elter, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Oberste, Max UNSPECIFIED UNSPECIFIED UNSPECIFIED Wolf, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Joisten, Niklas UNSPECIFIED orcid.org/0000-0002-9947-8746 UNSPECIFIED Hartig, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Walzik, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Rosenberger, Friederike UNSPECIFIED UNSPECIFIED UNSPECIFIED Kiesl, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Wahl, Patrick UNSPECIFIED orcid.org/0000-0001-8682-5916 UNSPECIFIED Bloch, Wilhelm UNSPECIFIED UNSPECIFIED UNSPECIFIED Zimmer, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-593162
DOI:	10.1007/s00520-021-06035-w
Journal or Publication Title:	Support. Care Cancer
Volume:	29
Number:	8
Page Range:	S. 4859 - 4867
Date:	2021
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1433-7339
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Oncology; Health Care Sciences & Services; Rehabilitation Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59316