Universität zu Köln

Scholz, Paula, Altay, Lebriz, Sitnilska, Vasilena, van Dijk, Elon H. C., Pereira, Alberto M. ORCID: 0000-0002-1194-9866, van Haalen, Femke M., Akhtar, Isha, Boon, Camiel J. F. and Fauser, Sascha (2021). SALIVARY ALPHA-AMYLASE LEVELS MAY CORRELATE WITH CENTRAL SEROUS CHORIORETINOPATHY ACTIVITY. Retin.-J. Retin. Vitr. Dis., 41 (12). S. 2479 - 2485. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1539-2864

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Abstract

Purpose: To investigate and compare the salivary alpha-amylase (sAA) activity as an indicator of the sympathetic activity and stress response in patients with central serous chorioretinopathy (CSC) and healthy control subjects. Methods: Prospective multicenter case series, including 80 CSC patients and 88 healthy control subjects. Central serous chorioretinopathy status was classified as either active or inactive, depending on the presence of subretinal fluid on optical coherence tomography. Salivary samples were collected in the morning from patients and control subjects of the main cohort and at midnight for the additional cohort. Salivary alpha-amylase activity was determined in all patients and control subjects. Results: Morning sAA activity was significantly higher in patients with active CSC compared with inactive CSC (P = 0.049) and to healthy control subjects (P = 0.012). There was no significant difference in sAA activity between patients with inactive CSC and control subjects (P = 1.0). Nocturnal sAA activity did not show any significant difference between patients with active CSC and either inactive CSC or control subjects (P = 0.139). Conclusion: Morning sAA activity is increased in patients with active CSC, although diurnal rhythmicity is preserved. Measurement of sAA is easy to perform and might be an eligible tool to further investigate the relation between stress and CSC.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Scholz, Paula UNSPECIFIED UNSPECIFIED UNSPECIFIED Altay, Lebriz UNSPECIFIED UNSPECIFIED UNSPECIFIED Sitnilska, Vasilena UNSPECIFIED UNSPECIFIED UNSPECIFIED van Dijk, Elon H. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pereira, Alberto M. UNSPECIFIED orcid.org/0000-0002-1194-9866 UNSPECIFIED van Haalen, Femke M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Akhtar, Isha UNSPECIFIED UNSPECIFIED UNSPECIFIED Boon, Camiel J. F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fauser, Sascha UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-593803
DOI:	10.1097/IAE.0000000000003266
Journal or Publication Title:	Retin.-J. Retin. Vitr. Dis.
Volume:	41
Number:	12
Page Range:	S. 2479 - 2485
Date:	2021
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1539-2864
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INDOCYANINE GREEN VIDEOANGIOGRAPHY; SUBTHRESHOLD MICROPULSE LASER; A-BEHAVIOR; STRESS Multiple languages Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59380