Universität zu Köln

Styczen, Hanna ORCID: 0000-0002-9623-4156, Gawlitza, Matthias, Abdullayev, Nuran ORCID: 0000-0003-4522-537X, Brehm, Alex, Serna-Candel, Carmen, Fischer, Sebastian, Gerber, Johannes ORCID: 0000-0001-7465-8700, Kabbasch, Christoph, Psychogios, Marios-Nikos, Forsting, Michael, Henkes, Hans and Maus, Volker (2021). Mechanical thrombectomy in acute ischaemic stroke patients with pre-interventional intracranial haemorrhage following intravenous thrombolysis. Neuradiology J., 34 (5). S. 456 - 462. THOUSAND OAKS: SAGE PUBLICATIONS INC. ISSN 2385-1996

Full text not available from this repository.

Abstract

Background: Data on outcome of endovascular treatment in patients with acute ischaemic stroke due to large vessel occlusion suffering from intravenous thrombolysis-associated intracranial haemorrhage prior to mechanical thrombectomy remain scarce. Addressing this subject, we report our multicentre experience. Methods: A retrospective analysis of consecutive acute ischaemic stroke patients treated with mechanical thrombectomy due to large vessel occlusion despite the pre-interventional occurrence of intravenous thrombolysis-associated intracranial haemorrhage was performed at five tertiary care centres between January 2010-September 2020. Baseline demographics, aetiology of stroke and intracranial haemorrhage, angiographic outcome assessed by the Thrombolysis in Cerebral Infarction score and clinical outcome evaluated by the modified Rankin Scale at 90 days were recorded. Results: In total, six patients were included in the study. Five individuals demonstrated cerebral intraparenchymal haemorrhage on pre-interventional imaging; in one patient additional subdural haematoma was observed and one patient suffered from isolated subarachnoid haemorrhage. All patients except one were treated by the 'drip-and-ship' paradigm. Successful reperfusion was achieved in 4/6 (67%) individuals. In 5/6 (83%) patients, the pre-interventional intracranial haemorrhage had aggravated in post-interventional computed tomography with space-occupying effect. Overall, five patients had died during the hospital stay. The clinical outcome of the survivor was modified Rankin Scale=4 at 90 days follow-up. Conclusion: Mechanical thrombectomy in patients with intravenous thrombolysis-associated intracranial haemorrhage is technically feasible. The clinical outcome of this subgroup of stroke patients, however, appears to be devastating with high mortality and only carefully selected patients might benefit from endovascular treatment.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Styczen, Hanna UNSPECIFIED orcid.org/0000-0002-9623-4156 UNSPECIFIED Gawlitza, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Abdullayev, Nuran UNSPECIFIED orcid.org/0000-0003-4522-537X UNSPECIFIED Brehm, Alex UNSPECIFIED UNSPECIFIED UNSPECIFIED Serna-Candel, Carmen UNSPECIFIED UNSPECIFIED UNSPECIFIED Fischer, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Gerber, Johannes UNSPECIFIED orcid.org/0000-0001-7465-8700 UNSPECIFIED Kabbasch, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Psychogios, Marios-Nikos UNSPECIFIED UNSPECIFIED UNSPECIFIED Forsting, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Henkes, Hans UNSPECIFIED UNSPECIFIED UNSPECIFIED Maus, Volker UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-593980
DOI:	10.1177/19714009211009112
Journal or Publication Title:	Neuradiology J.
Volume:	34
Number:	5
Page Range:	S. 456 - 462
Date:	2021
Publisher:	SAGE PUBLICATIONS INC
Place of Publication:	THOUSAND OAKS
ISSN:	2385-1996
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Neuroimaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59398