Universität zu Köln

Zhang, Liang, DeGennaro, Daniel, Lin, Guangzhong, Chai, Jijie ORCID: 0000-0001-7591-3873 and Shpak, Elena D. (2021). ERECTA family signaling constrains CLAVATA3 and WUSCHEL to the center of the shoot apical meristem. Development, 148 (5). CAMBRIDGE: COMPANY BIOLOGISTS LTD. ISSN 1477-9129

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Abstract

The shoot apical meristem (SAM) is a reservoir of stem cells that gives rise to all post-embryonic above-ground plant organs. The size of the SAM remains stable over time owing to a precise balance of stem cell replenishment versus cell incorporation into organ primordia. The WUSCHEL (WUS)/CLAVATA (CLV) negative feedback loop is central to SAM size regulation. Its correct function depends on accurate spatial expression of WUS and CLV3. A signaling pathway, consisting of ERECTA family (ERf) receptors and EPIDERMAL PATTERNING FACTOR LIKE (EPFL) ligands, restricts SAM width and promotes leaf initiation. Although ERf receptors are expressed throughout the SAM, EPFL ligands are expressed in its periphery. Our genetic analysis of Arabidopsis demonstrated that ERfs and CLV3 synergistically regulate the size of the SAM, and wus is epistatic to ERf genes. Furthermore, activation of ERf signaling with exogenous EPFLs resulted in a rapid decrease of CLV3 and WUS expression. ERf-EPFL signaling inhibits expression of WUS and CLV3 in the periphery of the SAM, confining them to the center. These findings establish the molecular mechanism for stem cell positioning along the radial axis.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zhang, Liang UNSPECIFIED UNSPECIFIED UNSPECIFIED DeGennaro, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Lin, Guangzhong UNSPECIFIED UNSPECIFIED UNSPECIFIED Chai, Jijie UNSPECIFIED orcid.org/0000-0001-7591-3873 UNSPECIFIED Shpak, Elena D. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-594108
DOI:	10.1242/dev.189753
Journal or Publication Title:	Development
Volume:	148
Number:	5
Date:	2021
Publisher:	COMPANY BIOLOGISTS LTD
Place of Publication:	CAMBRIDGE
ISSN:	1477-9129
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STEM-CELL HOMEOSTASIS; RECEPTOR-LIKE KINASE; ARABIDOPSIS SHOOT; STOMATAL DEVELOPMENT; SECRETORY PEPTIDE; PROTEIN; FATE; GENE; MAINTENANCE; EXPRESSION Multiple languages Developmental Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59410