Universität zu Köln

Ozarda, Yesim, Ichihara, Kiyoshi, Jones, Graham, Streichert, Thomas and Ahmadian, Robab ORCID: 0000-0003-1550-639X (2021). Comparison of reference intervals derived by direct and indirect methods based on compatible datasets obtained in Turkey. Clin. Chim. Acta, 520. S. 186 - 196. AMSTERDAM: ELSEVIER. ISSN 1873-3492

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Abstract

Background: Indirect derivation of reference intervals (RIs) from the laboratory information system (LIS) has been recently pursued. We aimed at evaluating the accuracy of indirectly predicted RIs compared to the RIs established directly from healthy subjects in the nationwide RI study in Turkey, targeting 25 major chemistry analytes. Methods: LIS data were retrieved from the laboratory that performed measurements for the direct study. They were cleaned by limiting to outpatients with age 18-65 years, and by allowing only one record per year per patient. Evaluated were four indirect methods of univariate approach: Hoffmann, Bhattacharya, Arzideh, and Wosniok methods. Power transformation of the LIS dataset was performed either using the power (lambda) reported by the IFCC global RI study (the first two methods) or using a lambda predicted (the last two). Results: Compared to the direct study dataset, the LIS dataset showed a variable degree of alterations in peak location and shape. Consequently, lower-side peak-shifts observed in sodium, albumin, etc. led to lowered RI limits, whereas higher-side peak-shift observed in triglyceride, low-density lipoprotein cholesterol, etc. led to raised RI limits. Overall, 72% (62-81) of the RI limits predicted by indirect methods showed significant biases from direct RIs. However, the biases observed in total cholesterol, lactic dehydrogenase, etc. were attributed to a higher-side age-bias in LIS dataset. After excluding them, the overall proportion of biased RIs was reduced to 47% (38-54). Conclusion: To reduce prediction biases that remained after age adjustment, it is necessary to apply more rigorous data-cleaning before applying indirect methods.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ozarda, Yesim UNSPECIFIED UNSPECIFIED UNSPECIFIED Ichihara, Kiyoshi UNSPECIFIED UNSPECIFIED UNSPECIFIED Jones, Graham UNSPECIFIED UNSPECIFIED UNSPECIFIED Streichert, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Ahmadian, Robab UNSPECIFIED orcid.org/0000-0003-1550-639X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-594306
DOI:	10.1016/j.cca.2021.05.030
Journal or Publication Title:	Clin. Chim. Acta
Volume:	520
Page Range:	S. 186 - 196
Date:	2021
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	1873-3492
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DERIVATION; MULTICENTER; INDIVIDUALS; TESTS Multiple languages Medical Laboratory Technology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59430