Universität zu Köln

Wirtz, Theresa H., Loosen, Sven H., Schulze-Hagen, Maximilian ORCID: 0000-0002-9182-2688, Weiskirchen, Ralf ORCID: 0000-0003-3888-0931, Buendgens, Lukas, Abu Jhaisha, Samira, Brozat, Jonathan F., Puengel, Tobias ORCID: 0000-0003-2662-6127, Vucur, Mihael, Paffenholz, Pia, Kuhl, Christiane, Tacke, Frank, Trautwein, Christian, Luedde, Tom, Roderburg, Christoph and Koch, Alexander (2021). CT-based determination of excessive visceral adipose tissue is associated with an impaired survival in critically ill patients. PLoS One, 16 (4). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Objective Obesity is a negative prognostic factor for various clinical conditions. In this observational cohort study, we evaluated a CT-based assessment of the adipose tissue distribution as a potential non-invasive prognostic parameter in critical illness. Methods Routine CT-scans upon admission to the intensive care unit (ICU) were used to analyze the visceral and subcutaneous adipose tissue areas at the 3(rd) lumbar vertebra in 155 patients. Results were correlated with various prognostic markers and both short-term- and overall survival. Multiple statistical tools were used for data analysis. Results We observed a significantly larger visceral adipose tissue area in septic patients compared to non-sepsis patients. Interestingly, patients requiring mechanical ventilation had a significantly higher amount of visceral adipose tissue correlating with the duration of mechanical ventilation. Moreover, both visceral and subcutaneous adipose tissue area significantly correlated with several laboratory markers. While neither the visceral nor the subcutaneous adipose tissue area was predictive for short-term ICU survival, patients with a visceral adipose tissue area above the optimal cut-off (241.4 cm(2)) had a significantly impaired overall survival compared to patients with a lower visceral adipose tissue area. Conclusions Our study supports a prognostic role of the individual adipose tissue distribution in critically ill patients. However, additional investigations need to confirm our suggestion that routine CT-based assessment of adipose tissue distribution can be used to yield further information on the patients' clinical course. Moreover, future studies should address functional and metabolic analysis of different adipose tissue compartments in critical illness.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wirtz, Theresa H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Loosen, Sven H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schulze-Hagen, Maximilian UNSPECIFIED orcid.org/0000-0002-9182-2688 UNSPECIFIED Weiskirchen, Ralf UNSPECIFIED orcid.org/0000-0003-3888-0931 UNSPECIFIED Buendgens, Lukas UNSPECIFIED UNSPECIFIED UNSPECIFIED Abu Jhaisha, Samira UNSPECIFIED UNSPECIFIED UNSPECIFIED Brozat, Jonathan F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Puengel, Tobias UNSPECIFIED orcid.org/0000-0003-2662-6127 UNSPECIFIED Vucur, Mihael UNSPECIFIED UNSPECIFIED UNSPECIFIED Paffenholz, Pia UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuhl, Christiane UNSPECIFIED UNSPECIFIED UNSPECIFIED Tacke, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Trautwein, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Luedde, Tom UNSPECIFIED UNSPECIFIED UNSPECIFIED Roderburg, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Koch, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-594313
DOI:	10.1371/journal.pone.0250321
Journal or Publication Title:	PLoS One
Volume:	16
Number:	4
Date:	2021
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BODY-MASS INDEX; WAIST CIRCUMFERENCE; ICU PATIENTS; FAT; METAANALYSIS; OVERWEIGHT; PARAMETERS; MORTALITY; OBESITY; SEX Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59431