Thelen, Martin ORCID: 0000-0002-2785-9726, Wennhold, Kerstin, Lehmann, Jonas, Garcia-Marquez, Maria, Klein, Sebastian ORCID: 0000-0002-2188-9377, Kochen, Elena ORCID: 0000-0003-2470-825X, Lohneis, Philipp, Lechner, Axel, Wagener-Ryczek, Svenja, Plum, Patrick Sven, Velazquez Camacho, Oscar, Pfister, David, Doerr, Fabian, Heldwein, Matthias, Hekmat, Khosro, Beutner, Dirk, Klussmann, Jens Peter, Thangarajah, Fabinshy, Ratiu, Dominik, Malter, Wolfram, Merkelbach-Bruse, Sabine, Bruns, Christiane Josephine, Quaas, Alexander, von Bergwelt-Baildon, Michael and Schloesser, Hans A. (2021). Cancer-specific immune evasion and substantial heterogeneity within cancer types provide evidence for personalized immunotherapy. npj Precis. Oncol., 5 (1). BERLIN: NATURE RESEARCH. ISSN 2397-768X

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Abstract

The immune response against cancer is orchestrated by various parameters and site-dependent specificities have been poorly investigated. In our analyses of ten different cancer types, we describe elevated infiltration by regulatory T cells as the most common feature, while other lymphocyte subsets and also expression of immune-regulatory molecules on tumor-infiltrating lymphocytes showed site-specific variation. Multiparametric analyses of these data identified similarities of renal and liver or lung with head and neck cancer. Co-expression of immune-inhibitory ligands on tumor cells was most frequent in colorectal, lung and ovarian cancer. Genes related to antigen presentation were frequently dysregulated in liver and lung cancer. Expression of co-inhibitory molecules on tumor-infiltrating T cells accumulated in advanced stages while T-cell abundance was related to enhanced expression of genes related to antigen presentation. Our results promote evaluation of cancer-specific or even personalized immunotherapeutic combinations to overcome primary or secondary resistance as major limitation of immune-checkpoint inhibition.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Thelen, MartinUNSPECIFIEDorcid.org/0000-0002-2785-9726UNSPECIFIED
Wennhold, KerstinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lehmann, JonasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garcia-Marquez, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klein, SebastianUNSPECIFIEDorcid.org/0000-0002-2188-9377UNSPECIFIED
Kochen, ElenaUNSPECIFIEDorcid.org/0000-0003-2470-825XUNSPECIFIED
Lohneis, PhilippUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lechner, AxelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wagener-Ryczek, SvenjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Plum, Patrick SvenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Velazquez Camacho, OscarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pfister, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Doerr, FabianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heldwein, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hekmat, KhosroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beutner, DirkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klussmann, Jens PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thangarajah, FabinshyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ratiu, DominikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Malter, WolframUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Merkelbach-Bruse, SabineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bruns, Christiane JosephineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Quaas, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
von Bergwelt-Baildon, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schloesser, Hans A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-594397
DOI: 10.1038/s41698-021-00196-x
Journal or Publication Title: npj Precis. Oncol.
Volume: 5
Number: 1
Date: 2021
Publisher: NATURE RESEARCH
Place of Publication: BERLIN
ISSN: 2397-768X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
PERIPHERAL-BLOOD; PD-1 BLOCKADE; EXPRESSION; TUMOR; CELLS; NIVOLUMAB; IMMUNOSCORE; LYMPHOCYTES; SENSITIVITY; RESISTANCEMultiple languages
OncologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/59439

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