Universität zu Köln

Hou, Shuguo, Liu, Derui ORCID: 0000-0001-5199-7814, Huang, Shijia, Luo, Dexian, Liu, Zunyong, Xiang, Qingyuan, Wang, Ping, Mu, Ruimin, Han, Zhifu, Chen, Sixue, Chai, Jijie, Shan, Libo and He, Ping (2021). The Arabidopsis MIK2 receptor elicits immunity by sensing a conserved signature from phytocytokines and microbes. Nat. Commun., 12 (1). BERLIN: NATURE PORTFOLIO. ISSN 2041-1723

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Abstract

Sessile plants encode a large number of small peptides and cell surface-resident receptor kinases, most of which have unknown functions. Here, we report that the Arabidopsis receptor kinase MALE DISCOVERER 1-INTERACTING RECEPTOR-LIKE KINASE 2 (MIK2) recognizes the conserved signature motif of SERINE-RICH ENDOGENOUS PEPTIDEs (SCOOPs) from Brassicaceae plants as well as proteins present in fungal Fusarium spp. and bacterial Comamonadaceae, and elicits various immune responses. SCOOP signature peptides trigger immune responses and altered root development in a MIK2-dependent manner with a sub-nanomolar sensitivity. SCOOP12 directly binds to the extracellular leucine-rich repeat domain of MIK2 in vivo and in vitro, indicating that MIK2 is the receptor of SCOOP peptides. Perception of SCOOP peptides induces the association of MIK2 and the coreceptors SOMATIC EMBRYOGENESIS RECEPTOR KINASE 3 (SERK3) and SERK4 and relays the signaling through the cytosolic receptor-like kinases BOTRYTIS-INDUCED KINASE 1 (BIK1) and AVRPPHB SUSCEPTIBLE1 (PBS1)-LIKE 1 (PBL1). Our study identifies a plant receptor that bears a dual role in sensing the conserved peptide motif from phytocytokines and microbial proteins via a convergent signaling relay to ensure a robust immune response. Peptide signals generated during plant microbe interactions can trigger immune responses in plants. Here the authors show that SCOOP12, a member of a family of peptides present in Brassicaceae plants, and SCOOP12-like motifs in Fusarium fungi, can trigger immune responses following perception by the MIK2 receptor kinase.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hou, Shuguo UNSPECIFIED UNSPECIFIED UNSPECIFIED Liu, Derui UNSPECIFIED orcid.org/0000-0001-5199-7814 UNSPECIFIED Huang, Shijia UNSPECIFIED UNSPECIFIED UNSPECIFIED Luo, Dexian UNSPECIFIED UNSPECIFIED UNSPECIFIED Liu, Zunyong UNSPECIFIED UNSPECIFIED UNSPECIFIED Xiang, Qingyuan UNSPECIFIED UNSPECIFIED UNSPECIFIED Wang, Ping UNSPECIFIED UNSPECIFIED UNSPECIFIED Mu, Ruimin UNSPECIFIED UNSPECIFIED UNSPECIFIED Han, Zhifu UNSPECIFIED UNSPECIFIED UNSPECIFIED Chen, Sixue UNSPECIFIED UNSPECIFIED UNSPECIFIED Chai, Jijie UNSPECIFIED UNSPECIFIED UNSPECIFIED Shan, Libo UNSPECIFIED UNSPECIFIED UNSPECIFIED He, Ping UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-594573
DOI:	10.1038/s41467-021-25580-w
Journal or Publication Title:	Nat. Commun.
Volume:	12
Number:	1
Date:	2021
Publisher:	NATURE PORTFOLIO
Place of Publication:	BERLIN
ISSN:	2041-1723
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PATTERN-RECOGNITION RECEPTORS; ELONGATION-FACTOR TU; NADPH OXIDASE RBOHD; PEPTIDE MIMICS; KINASE BIK1; PERCEPTION; FLAGELLIN; RESPONSES; PLANTS; ACTIVATION Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59457