Universität zu Köln

Luo, Wei, Liu, Suning, Zhang, Wenqiang, Yang, Liu, Huang, Jianhua ORCID: 0000-0001-6509-1765, Zhou, Shutang, Feng, Qili, Palli, Subba Reddy, Wang, Jian, Roth, Siegfried ORCID: 0000-0001-5772-3558 and Li, Sheng (2021). Juvenile hormone signaling promotes ovulation and maintains egg shape by inducing expression of extracellular matrix genes. Proc. Natl. Acad. Sci. U. S. A., 118 (39). WASHINGTON: NATL ACAD SCIENCES. ISSN 0027-8424

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Abstract

It is well documented that the juvenile hormone (JH) can function as a gonadotropic hormone that stimulates vitellogenesis by activating the production and uptake of vitellogenin in insects. Here, we describe a phenotype associated with mutations in the Drosophila JH receptor genes, Met and Gce: the accumulation of mature eggs with reduced egg length in the ovary. JH signaling is mainly activated in ovarian muscle cells and induces laminin gene expression in these cells. Meanwhile, JH signaling induces collagen IV gene expression in the adult fat body, from which collagen IV is secreted and deposited onto the ovarian muscles. Laminin locally and collagen IV remotely contribute to the assembly of ovarian muscle extracellular matrix (ECM); moreover, the ECM components are indispensable for ovarian muscle contraction. Furthermore, ovarian muscle contraction externally generates a mechanical force to promote ovulation and maintain egg shape. This work reveals an important mechanism for JHregulated insect reproduction.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Luo, Wei UNSPECIFIED UNSPECIFIED UNSPECIFIED Liu, Suning UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhang, Wenqiang UNSPECIFIED UNSPECIFIED UNSPECIFIED Yang, Liu UNSPECIFIED UNSPECIFIED UNSPECIFIED Huang, Jianhua UNSPECIFIED orcid.org/0000-0001-6509-1765 UNSPECIFIED Zhou, Shutang UNSPECIFIED UNSPECIFIED UNSPECIFIED Feng, Qili UNSPECIFIED UNSPECIFIED UNSPECIFIED Palli, Subba Reddy UNSPECIFIED UNSPECIFIED UNSPECIFIED Wang, Jian UNSPECIFIED UNSPECIFIED UNSPECIFIED Roth, Siegfried UNSPECIFIED orcid.org/0000-0001-5772-3558 UNSPECIFIED Li, Sheng UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-594627
DOI:	10.1073/pnas.2104461118
Journal or Publication Title:	Proc. Natl. Acad. Sci. U. S. A.
Volume:	118
Number:	39
Date:	2021
Publisher:	NATL ACAD SCIENCES
Place of Publication:	WASHINGTON
ISSN:	0027-8424
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language METHOPRENE-TOLERANT; TRANSCRIPTIONAL ACTIVATION; DROSOPHILA; RECEPTOR; ELONGATION; RESISTANCE; MOVEMENT; PATHWAY; BINDING; KINASE Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59462