Vanshylla, Kanika ORCID: 0000-0003-4552-9170, Di Cristanziano, Veronica, Kleipass, Franziska, Dewald, Felix, Schommers, Philipp ORCID: 0000-0003-3375-6800, Gieselmann, Lutz ORCID: 0000-0003-3699-3318, Gruell, Henning, Schlotz, Maike, Ercanoglu, Meryem S., Stumpf, Ricarda, Mayer, Petra, Zehner, Matthias, Heger, Eva, Johannis, Wibke, Horn, Carola, Suarez, Isabelle, Jung, Norma, Salomon, Susanne, Eberhardt, Kirsten Alexandra, Gathof, Birgit, Faetkenheuer, Gerd, Pfeifer, Nico, Eggeling, Ralf, Augustin, Max, Lehmann, Clara and Klein, Florian (2021). Kinetics and correlates of the neutralizing antibody response to SARS-CoV-2 infection in humans. Cell Host Microbe, 29 (6). S. 917 - 934. CAMBRIDGE: CELL PRESS. ISSN 1934-6069

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Abstract

Understanding antibody-based SARS-CoV-2 immunity is critical for overcoming the COVID-19 pandemic and informing vaccination strategies. We evaluated SARS-CoV-2 antibody dynamics over 10 months in 963 individuals who predominantly experienced mild COVID-19. Investigating 2,146 samples, we initially detected SARS-CoV-2 antibodies in 94.4% of individuals, with 82% and 79% exhibiting serum and IgG neutralization, respectively. Approximately 3% of individuals demonstrated exceptional SARS-CoV-2 neutralization, with these elite neutralizers also possessing SARS-CoV-1 cross-neutralizing IgG. Multivariate statistical modeling revealed age, symptomatic infection, disease severity, and gender as key factors predicting SARS-CoV-2-neutralizing activity. A loss of reactivity to the virus spike protein was observed in 13% of individuals 10 months after infection. Neutralizing activity had half-lives of 14.7 weeks in serum versus 31.4 weeks in purified IgG, indicating a rather long-term IgG antibody response. Our results demonstrate a broad spectrum in the initial SARS-CoV-2-neutralizing antibody response, with sustained antibodies in most individuals for 10 months after mild COVID-19.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Vanshylla, KanikaUNSPECIFIEDorcid.org/0000-0003-4552-9170UNSPECIFIED
Di Cristanziano, VeronicaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kleipass, FranziskaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dewald, FelixUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schommers, PhilippUNSPECIFIEDorcid.org/0000-0003-3375-6800UNSPECIFIED
Gieselmann, LutzUNSPECIFIEDorcid.org/0000-0003-3699-3318UNSPECIFIED
Gruell, HenningUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schlotz, MaikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ercanoglu, Meryem S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stumpf, RicardaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mayer, PetraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zehner, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heger, EvaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Johannis, WibkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Horn, CarolaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Suarez, IsabelleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jung, NormaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Salomon, SusanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eberhardt, Kirsten AlexandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gathof, BirgitUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Faetkenheuer, GerdUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pfeifer, NicoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eggeling, RalfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Augustin, MaxUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lehmann, ClaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klein, FlorianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-594979
DOI: 10.1016/j.chom.2021.04.015
Journal or Publication Title: Cell Host Microbe
Volume: 29
Number: 6
Page Range: S. 917 - 934
Date: 2021
Publisher: CELL PRESS
Place of Publication: CAMBRIDGE
ISSN: 1934-6069
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
COVID-19; IMMUNITY; DISEASEMultiple languages
Microbiology; Parasitology; VirologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/59497

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