Universität zu Köln

Roderburg, Christoph, Loosen, Sven H., Bednarsch, Jan, Alizai, Patrick H., Roeth, Anjali A. ORCID: 0000-0002-1670-7487, Schmitz, Sophia M., Vucur, Mihael, Luedde, Mark, Paffenholz, Pia, Tacke, Frank ORCID: 0000-0001-6206-0226, Trautwein, Christian, Ulmer, Tom F., Neumann, Ulf Peter and Luedde, Tom (2021). Levels of Circulating PD-L1 Are Decreased in Patients with Resectable Cholangiocarcinoma. Int. J. Mol. Sci., 22 (12). BASEL: MDPI. ISSN 1422-0067

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Abstract

Tumor resection represents the only curative treatment option for patients with biliary tract cancers (BTCs), including intrahepatic cholangiocarcinoma (CCA), perihilar and extrahepatic CCA and gallbladder cancer. However, many patients develop early tumor recurrence and are unlikely to benefit from surgery. Therefore, markers to identify ideal surgical candidates are urgently needed. Circulating programmed cell death 1 ligand 1 (PD-L1) has recently been associated with different malignancies, including pancreatic cancer which closely resembles BTC in terms of patients' prognosis and tumor biology. Here, we aim at evaluating a potential role of circulating PD-L1 as a novel biomarker for resectable BTC. Methods: Serum levels of PD-L1 were analyzed by ELISA in 73 BTC patients and 42 healthy controls. Results: Circulating levels of preoperative PD-L1 were significantly lower in patients with BTC compared to controls. Patients with low PD-L1 levels displayed a strong trend towards an impaired prognosis, and circulating PD-L1 was negatively correlated with experimental markers of promalignant tumor characteristics such as CCL1, CCL21, CCL25 and CCL26. For 37 out of 73 patients, postoperative PD-L1 levels were available. Interestingly, after tumor resection, circulating PD-L1 raised to almost normal levels. Notably, patients with further decreasing PD-L1 concentrations after surgery showed a trend towards an impaired postoperative outcome. Conclusion: Circulating PD-L1 levels were decreased in patients with resectable BTC. Lack of normalization of PD-L1 levels after surgery might identify patients at high risk for tumor recurrence or adverse outcome.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Roderburg, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Loosen, Sven H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bednarsch, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Alizai, Patrick H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Roeth, Anjali A. UNSPECIFIED orcid.org/0000-0002-1670-7487 UNSPECIFIED Schmitz, Sophia M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Vucur, Mihael UNSPECIFIED UNSPECIFIED UNSPECIFIED Luedde, Mark UNSPECIFIED UNSPECIFIED UNSPECIFIED Paffenholz, Pia UNSPECIFIED UNSPECIFIED UNSPECIFIED Tacke, Frank UNSPECIFIED orcid.org/0000-0001-6206-0226 UNSPECIFIED Trautwein, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Ulmer, Tom F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Neumann, Ulf Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Luedde, Tom UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-595336
DOI:	10.3390/ijms22126569
Journal or Publication Title:	Int. J. Mol. Sci.
Volume:	22
Number:	12
Date:	2021
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	1422-0067
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language OPEN-LABEL; MULTICENTER; PROGRESSION; EXPRESSION; SURVIVAL Multiple languages Biochemistry & Molecular Biology; Chemistry, Multidisciplinary Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59533