Universität zu Köln

Karczewski, Daniel ORCID: 0000-0002-7409-9002, Schnake, Klaus J., Osterhoff, Georg ORCID: 0000-0001-5051-0998, Spiegl, Ulrich, Scheyerer, Max J., Ullrich, Bernhard and Pumberger, Matthias ORCID: 0000-0002-0885-7370 . Postoperative Spinal Implant Infections (PSII)-A Systematic Review: What Do We Know So Far and What is Critical About It? Glob. Spine J.. LONDON: SAGE PUBLICATIONS LTD. ISSN 2192-5690

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Abstract

Study Design: Systematic review. Objectives: Postoperative spinal implant infections (PSII) are an increasing challenge in the daily clinical routine. This review summarizes existing knowledge in the field of PSII, including definitions, epidemiology, classifications, risk factors, pathogenesis, symptoms, diagnosis, and treatment. Methods: A systematic review was performed using a structured PubMed analysis, based on the PRISMA criteria. The search terminology was set as: spinal implant associated infection OR spinal implant infection OR spinal instrumentation infection OR peri spinal implant infection. PubMed search was limited to the categories randomized controlled trials (RCT), clinical trials, meta-analysis and (systematic) reviews, whereas case reports were excluded. Studies from January 2000 to December 2020 were considered eligible. A total of 572 studies were identified, 82 references included for qualitative synthesis, and 19 for detailed sub analysis (12 meta-analysis, 7 prospective RCT). Results: Structural problems in the field of PSII were revealed, including (1) limited level of evidence in clinical studies (missing prospective RCT, metanalyzes), (2) small patient numbers, (3) missing standardized definitions, (4) heterogeneity in patient groups, and (5) redundancy in cited literature. Conclusion: Evidence-based knowledge about spinal implant-associated infections is lacking. All involved medical fields should come together to define the term PSII and to combine their approaches toward research, training, and patient care.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Karczewski, Daniel UNSPECIFIED orcid.org/0000-0002-7409-9002 UNSPECIFIED Schnake, Klaus J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Osterhoff, Georg UNSPECIFIED orcid.org/0000-0001-5051-0998 UNSPECIFIED Spiegl, Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Scheyerer, Max J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ullrich, Bernhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Pumberger, Matthias UNSPECIFIED orcid.org/0000-0002-0885-7370 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-595424
DOI:	10.1177/21925682211024198
Journal or Publication Title:	Glob. Spine J.
Publisher:	SAGE PUBLICATIONS LTD
Place of Publication:	LONDON
ISSN:	2192-5690
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SURGICAL-SITE INFECTION; LUMBAR INTERBODY FUSION; ADOLESCENT IDIOPATHIC SCOLIOSIS; DEEP WOUND-INFECTION; RISK-FACTORS; SURGERY; FIXATION; EFFICACY; CONTAMINATION; PROPHYLAXIS Multiple languages Clinical Neurology; Orthopedics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59542