Universität zu Köln

Zopf, Eva M., Schulz, Holger, Poeschko, Jonas, Aschenbroich, Kerstin, Wilhelm, Thomas, Eypasch, Ernst, Kleimann, Elmar, Severin, Kai, Benz, Jutta, Liu, Enwu, Bloch, Wilhelm and Baumann, Freerk T. (2022). Effects of supervised aerobic exercise on cardiorespiratory fitness and patient-reported health outcomes in colorectal cancer patients undergoing adjuvant chemotherapy-a pilot study. Support. Care Cancer, 30 (3). S. 1945 - 1956. NEW YORK: SPRINGER. ISSN 1433-7339

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Abstract

Purpose Colorectal cancer and its treatment are associated with debilitating side effects. Exercise may improve the physical and psychological wellbeing of cancer patients; however, evidence in colorectal cancer patients undergoing adjuvant chemotherapy is limited. This pilot study aimed to explore the effects of supervised aerobic exercise on cardiorespiratory fitness and patient-reported health outcomes in colorectal cancer patients undergoing adjuvant chemotherapy. Methods Patients who had undergone curative resection for colorectal cancer (stages II-III) and were scheduled to receive adjuvant chemotherapy were enrolled into this non-randomized controlled trial. Patients in the intervention group (IG) took part in a 6-month supervised aerobic exercise program, while the control group (CG) received usual care. Cardiorespiratory fitness (measured by peak oxygen consumption) was assessed at baseline and 6 months. Fatigue, quality of life, and physical activity levels were additionally assessed at 3 months. Results In total, 59 patients (33 in IG vs. 26 in CG) were enrolled into this study. Eighteen patients (9 in IG vs. 9 in CG) dropped out of the study prior to the 6-month follow-up. Significant improvements in cardiorespiratory fitness (p = .002) and selected patient-reported health outcomes, such as reduced motivation (p = .015) and mental fatigue (p = .018), were observed in the IG when compared to the CG. Conclusion To our knowledge, this is the first study to investigate the effects of a supervised aerobic exercise program in colorectal cancer patients undergoing adjuvant chemotherapy. The significant and clinically meaningful improvements in CRF warrant further randomized controlled trials to confirm these findings.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zopf, Eva M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schulz, Holger UNSPECIFIED UNSPECIFIED UNSPECIFIED Poeschko, Jonas UNSPECIFIED UNSPECIFIED UNSPECIFIED Aschenbroich, Kerstin UNSPECIFIED UNSPECIFIED UNSPECIFIED Wilhelm, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Eypasch, Ernst UNSPECIFIED UNSPECIFIED UNSPECIFIED Kleimann, Elmar UNSPECIFIED UNSPECIFIED UNSPECIFIED Severin, Kai UNSPECIFIED UNSPECIFIED UNSPECIFIED Benz, Jutta UNSPECIFIED UNSPECIFIED UNSPECIFIED Liu, Enwu UNSPECIFIED UNSPECIFIED UNSPECIFIED Bloch, Wilhelm UNSPECIFIED UNSPECIFIED UNSPECIFIED Baumann, Freerk T. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-595527
DOI:	10.1007/s00520-021-06608-9
Journal or Publication Title:	Support. Care Cancer
Volume:	30
Number:	3
Page Range:	S. 1945 - 1956
Date:	2022
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1433-7339
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language QUALITY-OF-LIFE; III COLON-CANCER; PHYSICAL-EXERCISE; RANDOMIZED-TRIAL; BREAST-CANCER; STAGE-II; MORBIDITY; VALIDATION; MORTALITY; SURVIVORS Multiple languages Oncology; Health Care Sciences & Services; Rehabilitation Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59552