Universität zu Köln

Friedrich, Sarah-Kim, Schmitz, Rosa, Bergerhausen, Michael, Lang, Judith ORCID: 0000-0001-5352-106X, Duhan, Vikas ORCID: 0000-0002-6337-8225, Hardt, Cornelia, Tenbusch, Matthias ORCID: 0000-0003-3951-9056, Prinz, Marco, Asano, Kenichi, Bhat, Hilal, Hamdan, Thamer A., Lang, Philipp Alexander and Lang, Karl Sebastian (2021). Replication of Influenza A Virus in Secondary Lymphatic Tissue Contributes to Innate Immune Activation. Pathogens, 10 (5). BASEL: MDPI. ISSN 2076-0817

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Abstract

The replication of viruses in secondary lymphoid organs guarantees sufficient amounts of pattern-recognition receptor ligands and antigens to activate the innate and adaptive immune system. Viruses with broad cell tropism usually replicate in lymphoid organs; however, whether a virus with a narrow tropism relies on replication in the secondary lymphoid organs to activate the immune system remains not well studied. In this study, we used the artificial intravenous route of infection to determine whether Influenza A virus (IAV) replication can occur in secondary lymphatic organs (SLO) and whether such replication correlates with innate immune activation. Indeed, we found that IAV replicates in secondary lymphatic tissue. IAV replication was dependent on the expression of Sialic acid residues in antigen-presenting cells and on the expression of the interferon-inhibitor UBP43 (Usp18). The replication of IAV correlated with innate immune activation, resulting in IAV eradication. The genetic deletion of Usp18 curbed IAV replication and limited innate immune activation. In conclusion, we found that IAV replicates in SLO, a mechanism which allows innate immune activation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Friedrich, Sarah-Kim UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmitz, Rosa UNSPECIFIED UNSPECIFIED UNSPECIFIED Bergerhausen, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Lang, Judith UNSPECIFIED orcid.org/0000-0001-5352-106X UNSPECIFIED Duhan, Vikas UNSPECIFIED orcid.org/0000-0002-6337-8225 UNSPECIFIED Hardt, Cornelia UNSPECIFIED UNSPECIFIED UNSPECIFIED Tenbusch, Matthias UNSPECIFIED orcid.org/0000-0003-3951-9056 UNSPECIFIED Prinz, Marco UNSPECIFIED UNSPECIFIED UNSPECIFIED Asano, Kenichi UNSPECIFIED UNSPECIFIED UNSPECIFIED Bhat, Hilal UNSPECIFIED UNSPECIFIED UNSPECIFIED Hamdan, Thamer A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lang, Philipp Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Lang, Karl Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-595542
DOI:	10.3390/pathogens10050622
Journal or Publication Title:	Pathogens
Volume:	10
Number:	5
Date:	2021
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2076-0817
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CD8 T-CELLS; VIRAL REPLICATION; ANTIGEN PRESENTATION; DENDRITIC CELLS; NODE; LUNG; MICE; MACROPHAGES; DETERMINES; RESPONSES Multiple languages Microbiology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59554