Universität zu Köln

Holzgreve, Adrien, Albert, Nathalie L., Galldiks, Norbert and Suchorska, Bogdana (2021). Use of PET Imaging in Neuro-Oncological Surgery. Cancers, 13 (9). BASEL: MDPI. ISSN 2072-6694

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Abstract

Simple Summary The use of positron emission tomography (PET) imaging in neuro-oncological surgery is an exciting field with thriving perspectives. Increasing evidence exists for amino acid-based PET to facilitate interpretation of imaging findings following therapeutic interventions in patients with glioma and brain metastases. In meningioma patients, radiolabeled somatostatin receptor ligands provide an improved tumor tissue visualization in lesions located in the vicinity of the skull base and differentiate between scar tissue and tumor recurrence. Moreover, they can be applied as an individual treatment option in recurrent atypical and anaplastic meningioma not eligible for further surgery and radiotherapy. With a focus on its clinical application, this review provides an overview of the emerging field of PET imaging in neuro-oncological surgery. This review provides an overview of current applications and perspectives of PET imaging in neuro-oncological surgery. The past and future of PET imaging in the management of patients with glioma and brain metastases are elucidated with an emphasis on amino acid tracers, such as O-(2-[F-18]fluoroethyl)-L-tyrosine (F-18-FET). The thematic scope includes surgical resection planning, prognostication, non-invasive prediction of molecular tumor characteristics, depiction of intratumoral heterogeneity, response assessment, differentiation between tumor progression and treatment-related changes, and emerging new tracers. Furthermore, the role of PET using specific somatostatin receptor ligands for the management of patients with meningioma is discussed. Further advances in neuro-oncological imaging can be expected from promising new techniques, such as hybrid PET/MR scanners and the implementation of artificial intelligence methods, such as radiomics.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Holzgreve, Adrien UNSPECIFIED UNSPECIFIED UNSPECIFIED Albert, Nathalie L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Galldiks, Norbert UNSPECIFIED UNSPECIFIED UNSPECIFIED Suchorska, Bogdana UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-595620
DOI:	10.3390/cancers13092093
Journal or Publication Title:	Cancers
Volume:	13
Number:	9
Date:	2021
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2072-6694
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POSITRON-EMISSION-TOMOGRAPHY; TIME-TO-PEAK; O-(2-F-18-FLUOROETHYL)-L-TYROSINE PET; RESPONSE ASSESSMENT; RADIATION NECROSIS; PROGNOSTIC MARKER; BRAIN METASTASIS; MENINGIOMAS; TUMOR; THERAPY Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59562