Universität zu Köln

Dieckmann, Klaus-Peter, Dumlupinar, Cansu, Radtke, Arlo, Matthies, Cord, Pichler, Renate, Paffenholz, Pia, Sommer, Joerg, Winter, Alexander, Zengerling, Friedemann, Hennig, Finja, Wuelfing, Christian and Belge, Gazanfer (2022). Associations of serum levels of microRNA-371a-3p (M371) with risk factors for progression in nonseminomatous testicular germ cell tumours clinical stage 1. World J. Urol., 40 (2). S. 317 - 327. NEW YORK: SPRINGER. ISSN 1433-8726

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Abstract

Purpose Lymphovascular invasion (LV1) and presence of > 50% embryonal carcinoma (> 50% EC) represent risk factors for progression in patients with clinical stage 1 (CS1) nonseminomatous (NS) testicular germ cell tumours. As serum levels of microRNA-371a-3p (M371) are capable of detecting small amounts of GCT, we evaluated if LV1 and > 50% EC are associated with M371 levels. Methods M371 serum levels were measured postoperatively in 153 NS CS1 patients and both pre- and postoperatively in 131 patients. We registered the following factors: age, tumour size, LV status, > 50% EC, teratoma in primary, preoperative elevation of classical tumour markers. M371 expression was compared among subgroups. The ability of M371 to predict LV1 was calculated by receiver operating characteristics (ROC) curves. Multiple regression analysis was used to look for associations of M371 levels with other factors. Results Postoperatively elevated M371 levels were found in 29.4% of the patients, but were neither associated with LV status nor with > 50% EC. Likewise, relative decrease of M371 was not associated. ROC analysis of postoperative M371 levels revealed an AUC of 0.5 for the ability to predict LV1 while preoperative M371 had an AUC of 0.732. Multiple regression analysis revealed significant associations of preoperative M371 levels with LV status (p = 0.003), tumour size (p = 0.001), > 50% EC (p = 0.004), and teratoma component (p = 0.045). Conclusion Postoperatively elevated M371 levels are not associated with risk factors for progression in NS CS1 patients. However, the significant association of preoperative M371 expression with LV1 deserves further evaluation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Dieckmann, Klaus-Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Dumlupinar, Cansu UNSPECIFIED UNSPECIFIED UNSPECIFIED Radtke, Arlo UNSPECIFIED UNSPECIFIED UNSPECIFIED Matthies, Cord UNSPECIFIED UNSPECIFIED UNSPECIFIED Pichler, Renate UNSPECIFIED UNSPECIFIED UNSPECIFIED Paffenholz, Pia UNSPECIFIED UNSPECIFIED UNSPECIFIED Sommer, Joerg UNSPECIFIED UNSPECIFIED UNSPECIFIED Winter, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Zengerling, Friedemann UNSPECIFIED UNSPECIFIED UNSPECIFIED Hennig, Finja UNSPECIFIED UNSPECIFIED UNSPECIFIED Wuelfing, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Belge, Gazanfer UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-595961
DOI:	10.1007/s00345-021-03876-2
Journal or Publication Title:	World J. Urol.
Volume:	40
Number:	2
Page Range:	S. 317 - 327
Date:	2022
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1433-8726
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BIOMARKER; MIR-371A-3P; MICRORNAS Multiple languages Urology & Nephrology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59596