Illingworth, Christopher J. R., Hamilton, William L., Warne, Ben, Routledge, Matthew, Popay, Ashley, Jackson, Chris, Fieldman, Tom, Meredith, Luke W., Houldcroft, Charlotte J., Hosmillo, Myra, Jahun, Aminu S., Caller, Laura G., Caddy, Sarah L., Yakovleva, Anna, Hall, Grant, Khokhar, Fahad A., Feltwell, Theresa, Pinckert, Malte L., Georgana, Iliana, Chaudhry, Yasmin, Curran, Martin D., Parmar, Surendra, Sparkes, Dominic, Rivett, Lucy, Jones, Nick K., Sridhar, Sushmita, Forrest, Sally, Dymond, Tom, Grainger, Kayleigh, Workman, Chris, Ferris, Mark, Gkrania-Klotsas, Effrossyni ORCID: 0000-0002-0930-8330, Brown, Nicholas M., Weekes, Michael P., Baker, Stephen, Peacock, Sharon J., Goodfellow, Ian G., Gouliouris, Theodore ORCID: 0000-0002-2011-1205, de Angelis, Daniela and Torok, M. Estee (2021). Superspreaders drive the largest outbreaks of hospital onset COVID-19 infections. eLife, 10. CAMBRIDGE: eLIFE SCIENCES PUBL LTD. ISSN 2050-084X

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Abstract

SARS-CoV-2 is notable both for its rapid spread, and for the heterogeneity of its patterns of transmission, with multiple published incidences of superspreading behaviour. Here, we applied a novel network reconstruction algorithm to infer patterns of viral transmission occurring between patients and health care workers (HCWs) in the largest clusters of COVID-19 infection identified during the first wave of the epidemic at Cambridge University Hospitals NHS Foundation Trust, UK. Based upon dates of individuals reporting symptoms, recorded individual locations, and viral genome sequence data, we show an uneven pattern of transmission between individuals, with patients being much more likely to be infected by other patients than by HCWs. Further, the data were consistent with a pattern of superspreading, whereby 21% of individuals caused 80% of transmission events. Our study provides a detailed retrospective analysis of nosocomial SARS-CoV-2 transmission, and sheds light on the need for intensive and pervasive infection control procedures.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Illingworth, Christopher J. R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hamilton, William L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Warne, BenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Routledge, MatthewUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Popay, AshleyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jackson, ChrisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fieldman, TomUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meredith, Luke W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Houldcroft, Charlotte J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hosmillo, MyraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jahun, Aminu S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Caller, Laura G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Caddy, Sarah L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yakovleva, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hall, GrantUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Khokhar, Fahad A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Feltwell, TheresaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pinckert, Malte L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Georgana, IlianaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chaudhry, YasminUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Curran, Martin D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Parmar, SurendraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sparkes, DominicUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rivett, LucyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jones, Nick K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sridhar, SushmitaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Forrest, SallyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dymond, TomUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grainger, KayleighUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Workman, ChrisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ferris, MarkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gkrania-Klotsas, EffrossyniUNSPECIFIEDorcid.org/0000-0002-0930-8330UNSPECIFIED
Brown, Nicholas M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weekes, Michael P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baker, StephenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peacock, Sharon J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goodfellow, Ian G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gouliouris, TheodoreUNSPECIFIEDorcid.org/0000-0002-2011-1205UNSPECIFIED
de Angelis, DanielaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Torok, M. EsteeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-596465
DOI: 10.7554/eLife.67308
Journal or Publication Title: eLife
Volume: 10
Date: 2021
Publisher: eLIFE SCIENCES PUBL LTD
Place of Publication: CAMBRIDGE
ISSN: 2050-084X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
TRANSMISSION TREES; DISEASESMultiple languages
BiologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/59646

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