Universität zu Köln

Deumer, Undine-Sophie, Varesi, Angelica ORCID: 0000-0002-1246-2320, Floris, Valentina, Savioli, Gabriele ORCID: 0000-0002-8679-5435, Mantovani, Elisa ORCID: 0000-0003-3717-7697, Lopez-Carrasco, Paulina ORCID: 0000-0003-0914-7001, Rosati, Gian Marco, Prasad, Sakshi ORCID: 0000-0002-1014-9031 and Ricevuti, Giovanni (2021). Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): An Overview. J. Clin. Med., 10 (20). BASEL: MDPI. ISSN 2077-0383

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Abstract

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic systemic disease that manifests via various symptoms such as chronic fatigue, post-exertional malaise, and cognitive impairment described as brain fog . These symptoms often prevent patients from keeping up their pre-disease onset lifestyle, as extended periods of physical or mental activity become almost impossible. However, the disease presents heterogeneously with varying severity across patients. Therefore, consensus criteria have been designed to provide a diagnosis based on symptoms. To date, no biomarker-based tests or diagnoses are available, since the molecular changes observed also largely differ from patient to patient. In this review, we discuss the infectious, genetic, and hormonal components that may be involved in CFS pathogenesis, we scrutinize the role of gut microbiota in disease progression, we highlight the potential of non-coding RNA (ncRNA) for the development of diagnostic tools and briefly mention the possibility of SARS-CoV-2 infection causing CFS.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Deumer, Undine-Sophie UNSPECIFIED UNSPECIFIED UNSPECIFIED Varesi, Angelica UNSPECIFIED orcid.org/0000-0002-1246-2320 UNSPECIFIED Floris, Valentina UNSPECIFIED UNSPECIFIED UNSPECIFIED Savioli, Gabriele UNSPECIFIED orcid.org/0000-0002-8679-5435 UNSPECIFIED Mantovani, Elisa UNSPECIFIED orcid.org/0000-0003-3717-7697 UNSPECIFIED Lopez-Carrasco, Paulina UNSPECIFIED orcid.org/0000-0003-0914-7001 UNSPECIFIED Rosati, Gian Marco UNSPECIFIED UNSPECIFIED UNSPECIFIED Prasad, Sakshi UNSPECIFIED orcid.org/0000-0002-1014-9031 UNSPECIFIED Ricevuti, Giovanni UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-597035
DOI:	10.3390/jcm10204786
Journal or Publication Title:	J. Clin. Med.
Volume:	10
Number:	20
Date:	2021
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2077-0383
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language COGNITIVE-BEHAVIOR THERAPY; TUMOR-NECROSIS-FACTOR; FECAL MICROBIOTA TRANSPLANTATION; PARVOVIRUS B19 INFECTION; NATURAL-KILLER-CELLS; INTESTINAL MICROBIOTA; CENTRAL SENSITIZATION; MULTIPLE-SCLEROSIS; NITROSATIVE STRESS; MAJOR DEPRESSION Multiple languages Medicine, General & Internal Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59703