Universität zu Köln

Cannatelli, Rosanna, Bazarova, Alina, Zardo, Davide, Nardone, Olga Maria, Shivaji, Uday, Smith, Samuel Charles Lloyd, Gkoutos, Georgios ORCID: 0000-0002-2061-091X, Ricci, Chiara, Gui, Xianyong Sean, Ghosh, Subrata ORCID: 0000-0002-1713-7797 and Iacucci, Marietta (2021). Fecal Calprotectin Thresholds to Predict Endoscopic Remission Using Advanced Optical Enhancement Techniques and Histological Remission in IBD Patients. Inflamm. Bowel Dis., 27 (5). S. 647 - 655. CARY: OXFORD UNIV PRESS INC. ISSN 1536-4844

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Abstract

Background: Fecal calprotectin (FC) is a common surrogate marker of mucosal healing (MH) in patients with ulcerative colitis (UC) and Crohn's disease (CD). We investigated the optimum FC thresholds for defining endoscopic remission (ER) and histological remission (HR) using advanced endoscopic techniques. Patients and Methods: In this cross-sectional study, we collected clinical, endoscopic, histological data, and FC from 76 UC and 41 CD patients. Receiver operating characteristic curves were created to evaluate the optimum cut-off of FC to predict ER evaluated by Mayo Endoscopic Score (MES), Ulcerative Colitis Endoscopic Index of Severity (UCEIS), and modified PICaSSO (Paddington International Virtual Chromoendoscopy Score) for UC patients and Simple Endoscopic Score (SES-CD) in CD patients; and HR was scored by the Robarts Histology Index (RHI) and Nancy Index for UC and modified Riley for CD. Results: In UC patients, the best thresholds of FC to identify ER calculated with MES, UCEIS, and modified PICaSSO were 112, 148, and 161 mcg/g with accuracy of 86.9% 86.8%, and 81.6%, respectively. The best value of FC to predict HR was 112 mcg/g and 172 mcg/g with accuracy of 84.2% and 81.6% for RHI and Nancy Index, respectively. In CD patients, the best cut-off of FC to predict ER was 96 mcg/g with accuracy of 82.9%. The HR was best predicted by an FC value of 225 mcg/g with accuracy of 75.6%. Conclusions: The FC value threshold between 112 and 172 mcg/g could identify ER and HR in UC patients, whereas a value under 225 mcg/g should be considered for CD patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Cannatelli, Rosanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Bazarova, Alina UNSPECIFIED UNSPECIFIED UNSPECIFIED Zardo, Davide UNSPECIFIED UNSPECIFIED UNSPECIFIED Nardone, Olga Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Shivaji, Uday UNSPECIFIED UNSPECIFIED UNSPECIFIED Smith, Samuel Charles Lloyd UNSPECIFIED UNSPECIFIED UNSPECIFIED Gkoutos, Georgios UNSPECIFIED orcid.org/0000-0002-2061-091X UNSPECIFIED Ricci, Chiara UNSPECIFIED UNSPECIFIED UNSPECIFIED Gui, Xianyong Sean UNSPECIFIED UNSPECIFIED UNSPECIFIED Ghosh, Subrata UNSPECIFIED orcid.org/0000-0002-1713-7797 UNSPECIFIED Iacucci, Marietta UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-597048
DOI:	10.1093/ibd/izaa163
Journal or Publication Title:	Inflamm. Bowel Dis.
Volume:	27
Number:	5
Page Range:	S. 647 - 655
Date:	2021
Publisher:	OXFORD UNIV PRESS INC
Place of Publication:	CARY
ISSN:	1536-4844
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ULCERATIVE-COLITIS; CROHNS-DISEASE; MUCOSAL; RELAPSE; INDEX; METAANALYSIS; RELIABILITY; LACTOFERRIN; RECURRENCE; INDICATORS Multiple languages Gastroenterology & Hepatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59704