Universität zu Köln

van der Heijden, Heleen S., Schirmbeck, Frederike ORCID: 0000-0003-1700-0958, Kempton, Matthew J., van der Gaag, Mark ORCID: 0000-0002-3525-6415, Allot, Kelly, Nelson, Barnaby ORCID: 0000-0002-6263-2332, Ruhrmann, Stephan ORCID: 0000-0002-6022-2364, de Haan, Lieuwe and Vermeulen, Jentien M. (2021). Impact of smoking Behavior on cognitive functioning in persons at risk for psychosis and healthy controls: A longitudinal study. Eur. Psychiat., 64 (1). CAMBRIDGE: CAMBRIDGE UNIV PRESS. ISSN 1778-3585

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Abstract

Background The high prevalence of smoking in individuals who are at ultra-high risk (UHR) for psychosis is well known and moderate cognitive deficits have also been found in UHR. However, the association between smoking and cognition in UHR is unknown and longitudinal studies are lacking. Method A cohort study with 330 UHR individuals and 66 controls was conducted, as part of the European network of national schizophrenia networks studying gene-environment interactions (EU-GEI). At baseline and after 6, 12, and 24 months, smoking behavior was assessed with the Composite International Diagnostic Interview and cognitive functioning with a comprehensive test battery. Linear mixed-effects analyses were used to examine the multicross-sectional and prospective associations between (change in) smoking behavior and cognitive functioning, accounting for confounding variables. Results At baseline, 53% of UHR and 27% of controls smoked tobacco. Smoking UHR and controls did not significantly differ from nonsmoking counterparts on the tested cognitive domains (speed of processing, attention/vigilance, working memory, verbal learning, or reasoning/problem solving) across different assessment times. Neither smoking cessation nor initiation was associated with a significant change in cognitive functioning in UHR. Conclusions No associations were found between smoking and cognitive impairment in UHR nor in controls. However, the fact that one in every two UHR individuals report daily use of tobacco is alarming. Our data suggest that UHR have fewer cognitive impairments and higher smoking cessation rates compared to patients with first-episode psychosis found in literature. Implications to promote smoking cessation in the UHR stage need further investigation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code van der Heijden, Heleen S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schirmbeck, Frederike UNSPECIFIED orcid.org/0000-0003-1700-0958 UNSPECIFIED Kempton, Matthew J. UNSPECIFIED UNSPECIFIED UNSPECIFIED van der Gaag, Mark UNSPECIFIED orcid.org/0000-0002-3525-6415 UNSPECIFIED Allot, Kelly UNSPECIFIED UNSPECIFIED UNSPECIFIED Nelson, Barnaby UNSPECIFIED orcid.org/0000-0002-6263-2332 UNSPECIFIED Ruhrmann, Stephan UNSPECIFIED orcid.org/0000-0002-6022-2364 UNSPECIFIED de Haan, Lieuwe UNSPECIFIED UNSPECIFIED UNSPECIFIED Vermeulen, Jentien M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-597377
DOI:	10.1192/j.eurpsy.2021.2233
Journal or Publication Title:	Eur. Psychiat.
Volume:	64
Number:	1
Date:	2021
Publisher:	CAMBRIDGE UNIV PRESS
Place of Publication:	CAMBRIDGE
ISSN:	1778-3585
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ULTRA-HIGH RISK; TOBACCO SMOKING; CIGARETTE-SMOKING; AT-RISK; SCHIZOPHRENIA; ASSOCIATION; RELIABILITY; PERFORMANCE; AGE; NEUROCOGNITION Multiple languages Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59737