Universität zu Köln

Takou, Margarita ORCID: 0000-0001-6176-6251, Hamala, Tuomas, Koch, Evan M., Steige, Kim A., Dittberner, Hannes, Yant, Levi, Genete, Mathieu, Sunyaev, Shamil, Castric, Vincent, Vekemans, Xavier ORCID: 0000-0002-4836-4394, Savolainen, Outi and de Meaux, Juliette ORCID: 0000-0002-2942-4750 (2021). Maintenance of Adaptive Dynamics and No Detectable Load in a Range-Edge Outcrossing Plant Population. Mol. Biol. Evol., 38 (5). S. 1820 - 1837. OXFORD: OXFORD UNIV PRESS. ISSN 1537-1719

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Abstract

During range expansion, edge populations are expected to face increased genetic drift, which in turn can alter and potentially compromise adaptive dynamics, preventing the removal of deleterious mutations and slowing down adaptation. Here, we contrast populations of the European subspecies Arabidopsis lyrata ssp. petraea, which expanded its Northern range after the last glaciation. We document a sharp decline in effective population size in the range-edge population and observe that nonsynonymous variants segregate at higher frequencies. We detect a 4.9% excess of derived nonsynonymous variants per individual in the range-edge population, suggesting an increase of the genomic burden of deleterious mutations. Inference of the fitness effects of mutations and modeling of allele frequencies under the explicit demographic history of each population predicts a depletion of rare deleterious variants in the range-edge population, but an enrichment for fixed ones, consistent with the bottleneck effect. However, the demographic history of the range-edge population predicts a small net decrease in per-individual fitness. Consistent with this prediction, the range-edge population is not impaired in its growth and survival measured in a common garden experiment. We further observe that the allelic diversity at the self-incompatibility locus, which ensures strict outcrossing and evolves under negative frequency-dependent selection, has remained unchanged. Genomic footprints indicative of selective sweeps are broader in the Northern population but not less frequent. We conclude that the outcrossing species A. lyrata ssp. petraea shows a strong resilience to the effect of range expansion.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Takou, Margarita UNSPECIFIED orcid.org/0000-0001-6176-6251 UNSPECIFIED Hamala, Tuomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Koch, Evan M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Steige, Kim A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dittberner, Hannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Yant, Levi UNSPECIFIED UNSPECIFIED UNSPECIFIED Genete, Mathieu UNSPECIFIED UNSPECIFIED UNSPECIFIED Sunyaev, Shamil UNSPECIFIED UNSPECIFIED UNSPECIFIED Castric, Vincent UNSPECIFIED UNSPECIFIED UNSPECIFIED Vekemans, Xavier UNSPECIFIED orcid.org/0000-0002-4836-4394 UNSPECIFIED Savolainen, Outi UNSPECIFIED UNSPECIFIED UNSPECIFIED de Meaux, Juliette UNSPECIFIED orcid.org/0000-0002-2942-4750 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-597566
DOI:	10.1093/molbev/msaa322
Journal or Publication Title:	Mol. Biol. Evol.
Volume:	38
Number:	5
Page Range:	S. 1820 - 1837
Date:	2021
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	1537-1719
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DELETERIOUS MUTATION LOAD; ARABIDOPSIS-LYRATA; SELF-INCOMPATIBILITY; INBREEDING DEPRESSION; NATURAL-POPULATIONS; GENETIC DIVERSITY; SELECTIVE SWEEPS; DEMOGRAPHIC HISTORY; POSITIVE SELECTION; GENUS ARABIDOPSIS Multiple languages Biochemistry & Molecular Biology; Evolutionary Biology; Genetics & Heredity Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59756