Hussain, Tarique, Wang, Jing, Murtaza, Ghulam, Metwally, Elsayed ORCID: 0000-0002-7471-3148, Yang, Huansheng, Kalhoro, Muhammad Saleem, Kalhoro, Dildar Hussain, Rahu, Baban Ali, Tan, Bie ORCID: 0000-0003-0138-1530, Sahito, Raja Ghazanfar Ali, Chughtai, Muhammad Ismail and Yin, Yulong (2021). The Role of Polyphenols in Regulation of Heat Shock Proteins and Gut Microbiota in Weaning Stress. Oxidative Med. Cell. Longev., 2021. LONDON: HINDAWI LTD. ISSN 1942-0994

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Abstract

Gut microbiota is the natural residents of the intestinal ecosystem which display multiple functions that provide beneficial effects on host physiology. Disturbances in gut microbiota in weaning stress are regulated by the immune system and oxidative stress-related protein pathways. Weaning stress also alters gut microbiota response, limits digestibility, and influences animal productive performance through the production of inflammatory molecules. Heat shock proteins are the molecular chaperones that perform array functions from physiological to pathological point of view and remodeling cellular stress response. As it is involved in the defense mechanism, polyphenols ensure cellular tolerance against enormous stimuli. Polyphenols are nature-blessed compounds that show their existence in plenty of amounts. Due to their wider availability and popularity, they can exert strong immunomodulatory, antioxidative, and anti-inflammatory activities. Their promising health-promoting effects have been demonstrated in different cellular and animal studies. Dietary interventions with polyphenols may alter the gut microbiome response and attenuate the weaning stress related to inflammation. Further, polyphenols elicit health-favored effects through ameliorating inflammatory processes to improve digestibility and thereby exert a protective effect on animal production. Here, in this article, we will expand the role of dietary polyphenol intervention strategies in weaning stress which perturbs gut microbiota function and also paid emphasis to heat shock proteins in gut health. This review article gives new direction to the feed industry to formulate diet containing polyphenols which would have a significant impact on animal health.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Hussain, TariqueUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wang, JingUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Murtaza, GhulamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Metwally, ElsayedUNSPECIFIEDorcid.org/0000-0002-7471-3148UNSPECIFIED
Yang, HuanshengUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kalhoro, Muhammad SaleemUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kalhoro, Dildar HussainUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rahu, Baban AliUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tan, BieUNSPECIFIEDorcid.org/0000-0003-0138-1530UNSPECIFIED
Sahito, Raja Ghazanfar AliUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chughtai, Muhammad IsmailUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yin, YulongUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-597607
DOI: 10.1155/2021/6676444
Journal or Publication Title: Oxidative Med. Cell. Longev.
Volume: 2021
Date: 2021
Publisher: HINDAWI LTD
Place of Publication: LONDON
ISSN: 1942-0994
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
INTESTINAL BARRIER FUNCTION; GROWTH-PERFORMANCE; KAPPA-B; WINE POLYPHENOLS; OXIDATIVE STRESS; MEDIATED INFLAMMATION; TRANS-RESVERATROL; EXTRACTION JUICES; ANTIOXIDANT BLEND; TEA POLYPHENOLSMultiple languages
Cell BiologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/59760

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