Universität zu Köln

Gratl, Alexandra ORCID: 0000-0002-0533-3387, Wipper, Sabine ORCID: 0000-0003-1345-5947, Frese, Jan Paul ORCID: 0000-0002-2690-0731, Raude, Ben, Greiner, Andreas and Pesta, Dominik ORCID: 0000-0002-5089-3586 (2021). The Role of Mitochondrial Function in Peripheral Arterial Disease: Insights from Translational Studies. Int. J. Mol. Sci., 22 (16). BASEL: MDPI. ISSN 1422-0067

Full text not available from this repository.

Abstract

Recent evidence demonstrates an involvement of impaired mitochondrial function in peripheral arterial disease (PAD) development. Specific impairments have been assessed by different methodological in-vivo (near-infrared spectroscopy, P-31 magnetic resonance spectroscopy), as well as in-vitro approaches (Western blotting of mitochondrial proteins and enzymes, assays of mitochondrial function and content). While effects differ with regard to disease severity, chronic malperfusion impacts subcellular energy homeostasis, and repeating cycles of ischemia and reperfusion contribute to PAD disease progression by increasing mitochondrial reactive oxygen species production and impairing mitochondrial function. With the leading clinical symptom of decreased walking capacity due to intermittent claudication, PAD patients suffer from a subsequent reduction of quality of life. Different treatment modalities, such as physical activity and revascularization procedures, can aid mitochondrial recovery. While the relevance of these modalities for mitochondrial functional recovery is still a matter of debate, recent research indicates the importance of revascularization procedures, with increased physical activity levels being a subordinate contributor, at least during mild stages of PAD. With an additional focus on the role of revascularization procedures on mitochondria and the identification of suitable mitochondrial markers in PAD, this review aims to critically evaluate the relevance of mitochondrial function in PAD development and progression.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gratl, Alexandra UNSPECIFIED orcid.org/0000-0002-0533-3387 UNSPECIFIED Wipper, Sabine UNSPECIFIED orcid.org/0000-0003-1345-5947 UNSPECIFIED Frese, Jan Paul UNSPECIFIED orcid.org/0000-0002-2690-0731 UNSPECIFIED Raude, Ben UNSPECIFIED UNSPECIFIED UNSPECIFIED Greiner, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Pesta, Dominik UNSPECIFIED orcid.org/0000-0002-5089-3586 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-597743
DOI:	10.3390/ijms22168478
Journal or Publication Title:	Int. J. Mol. Sci.
Volume:	22
Number:	16
Date:	2021
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	1422-0067
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MAGNETIC-RESONANCE-SPECTROSCOPY; ENERGY PHOSPHATE-METABOLISM; HIGH-RESOLUTION RESPIROMETRY; INCREMENTAL CALF EXERCISE; SKELETAL-MUSCLE; REPERFUSION INJURY; OCCLUSIVE DISEASE; FINE-STRUCTURE; ISCHEMIA; CLAUDICATION Multiple languages Biochemistry & Molecular Biology; Chemistry, Multidisciplinary Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59774