Universität zu Köln

Neirich, Leonie ORCID: 0000-0003-3703-8726, Yahiaoui-Doktor, Maryam, Lammert, Jacqueline, Basrai, Maryam, Seethaler, Benjamin, Berling-Ernst, Anika, Ramser, Juliane, Quante, Anne S., Schmidt, Thorsten, Niederberger, Uwe ORCID: 0000-0003-3099-0183, Rhiem, Kerstin, Schmutzler, Rita, Engel, Christoph ORCID: 0000-0002-7247-282X, Bischoff, Stephan C., Halle, Martin, Kiechle, Marion and Grill, Sabine (2021). Physical activity and Mediterranean diet as potential modulators of osteoprotegerin and soluble RANKL in gBRCA1/2 mutation carriers: results of the lifestyle intervention pilot study LIBRE-1. Breast Cancer Res. Treat., 190 (3). S. 463 - 476. NEW YORK: SPRINGER. ISSN 1573-7217

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Abstract

Purpose Emerging evidence suggests that the progesterone-mediated receptor activator of nuclear factor kappa B (RANK)/soluble RANK ligand (sRANKL)/osteoprotegerin (OPG) pathway plays an important role in mammary carcinogenesis and is hyperactivated in germline (g)BRCA1/2 mutation carriers. We analyzed the effects of a 3-month intensive lifestyle intervention within the LIBRE-1 study on the serum levels of OPG and sRANKL and hypothesized that the intervention program provides a beneficial impact on the biomarkers by increasing OPG and reducing sRANKL serum concentrations. Methods Serum levels of OPG and sRANKL of 49 gBRCA1/2 mutation carriers were quantified using enzyme-linked immunosorbent assays. We used previously collected blood samples from participants of the prospective LIBRE-1 study, who were randomized into an intervention group (IG), increasing physical activity and adherence to the Mediterranean diet (MedD) through supervised sessions from study entry to the first study visit after 3 months and a usual-care control group (CG). Differences in biomarker levels before and after the 3-month intervention were tested within and between study groups. Results The lifestyle intervention resulted in a significant increase in OPG for participants in both the IG (q = 0.022) and CG (q = 0.002). sRANKL decreased significantly in the IG (q = 0.0464) and seemed to decrease in the CG (q = 0.5584). An increase in the intake of Omega-3 polyunsaturated fatty acids was significantly associated with an increase in OPG (r = 0.579, q = 0.045). Baseline serum levels of sRANKL were a strong predictor for the change of sRANKL in the course of the intervention (ss-estimate = - 0.70; q = 0.0018). Baseline physical fitness (assessed as VO(2)peak) might predict the change of OPG in the course of the intervention program (ss-estimate = 0.133 pg/ml/ml/min/kg; p = 0.0319; q = 0.2871). Conclusion Findings from this pilot study seem to confirm our hypothesis by showing an increase in OPG and decrease in sRANKL over a 3-month lifestyle intervention and suggest that increased physical activity and adherence to the MedD are potent modulators of the biomarkers OPG and potentially sRANKL.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Neirich, Leonie UNSPECIFIED orcid.org/0000-0003-3703-8726 UNSPECIFIED Yahiaoui-Doktor, Maryam UNSPECIFIED UNSPECIFIED UNSPECIFIED Lammert, Jacqueline UNSPECIFIED UNSPECIFIED UNSPECIFIED Basrai, Maryam UNSPECIFIED UNSPECIFIED UNSPECIFIED Seethaler, Benjamin UNSPECIFIED UNSPECIFIED UNSPECIFIED Berling-Ernst, Anika UNSPECIFIED UNSPECIFIED UNSPECIFIED Ramser, Juliane UNSPECIFIED UNSPECIFIED UNSPECIFIED Quante, Anne S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Niederberger, Uwe UNSPECIFIED orcid.org/0000-0003-3099-0183 UNSPECIFIED Rhiem, Kerstin UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmutzler, Rita UNSPECIFIED UNSPECIFIED UNSPECIFIED Engel, Christoph UNSPECIFIED orcid.org/0000-0002-7247-282X UNSPECIFIED Bischoff, Stephan C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Halle, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Kiechle, Marion UNSPECIFIED UNSPECIFIED UNSPECIFIED Grill, Sabine UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-597896
DOI:	10.1007/s10549-021-06400-7
Journal or Publication Title:	Breast Cancer Res. Treat.
Volume:	190
Number:	3
Page Range:	S. 463 - 476
Date:	2021
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1573-7217
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language N-3 FATTY-ACIDS; KAPPA-B LIGAND; BREAST-CANCER RISK; RECEPTOR ACTIVATOR; SERUM OSTEOPROTEGERIN; DOCOSAHEXAENOIC ACID; RESISTANCE EXERCISE; AEROBIC EXERCISE; BRCA1 MUTATION; STEM-CELLS Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59789