Universität zu Köln

Loosen, Sven H., Roderburg, Christoph, Alizai, Patrick H., Roeth, Anjali A., Schmitz, Sophia M., Vucur, Mihael, Luedde, Mark, Schoeler, David, Paffenholz, Pia, Tacke, Frank ORCID: 0000-0001-6206-0226, Trautwein, Christian, Luedde, Tom, Neumann, Ulf P. and Ulmer, Tom F. (2021). Comparative Analysis of Circulating Biomarkers for Patients Undergoing Resection of Colorectal Liver Metastases. Diagnostics, 11 (11). BASEL: MDPI. ISSN 2075-4418

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Abstract

Surgical tumor resection has evolved as a potentially curative therapy for patients with resectable colorectal liver metastases (CRLM). However, disease recurrence is common and the available preoperative stratification strategies are often imprecise to identify the ideal candidates for surgical treatment, resulting in a postoperative 5-year survival rate below 50%. Data on the prognostic value of CEA, CA19-9 and other common laboratory parameters after CRLM resection are scarce and partly inconclusive. Here, we analyzed the prognostic potential of circulating CEA and CA19-9 in comparison to other standard laboratory markers in resectable CRLM patients. Serum levels of tumor markers and other laboratory parameters were analyzed in 125 patients with CRLM undergoing tumor resection at a tertiary referral center. Results were correlated with clinical data and outcome. Both tumor markers were significantly elevated in CRLM patients compared to healthy controls. Interestingly, elevated levels of CEA, CA19-9 and C-reactive protein (CRP) were associated with an unfavorable prognosis after CRLM resection in Kaplan-Meier curve analysis. However, only CEA and not CA19-9 or CRP serum levels were an independent prognostic marker in multivariate Cox regression analysis. Our data demonstrate that circulating levels of CEA rather than CA19-9 might be a valuable addition to the existing preoperative stratification algorithms to identify patients with a poor prognosis after CRLM resection.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Loosen, Sven H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Roderburg, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Alizai, Patrick H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Roeth, Anjali A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmitz, Sophia M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Vucur, Mihael UNSPECIFIED UNSPECIFIED UNSPECIFIED Luedde, Mark UNSPECIFIED UNSPECIFIED UNSPECIFIED Schoeler, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Paffenholz, Pia UNSPECIFIED UNSPECIFIED UNSPECIFIED Tacke, Frank UNSPECIFIED orcid.org/0000-0001-6206-0226 UNSPECIFIED Trautwein, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Luedde, Tom UNSPECIFIED UNSPECIFIED UNSPECIFIED Neumann, Ulf P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ulmer, Tom F. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-597973
DOI:	10.3390/diagnostics11111999
Journal or Publication Title:	Diagnostics
Volume:	11
Number:	11
Date:	2021
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2075-4418
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HEPATIC RESECTION; TUMOR-MARKERS; CANCER; CEA; METAANALYSIS; GUIDELINES; PROGRESS; SURGERY; IMPACT; STAGE Multiple languages Medicine, General & Internal Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59797