Universität zu Köln

Kamel, Walaa A., Majumdar, Pritam, Matis, Georgios ORCID: 0000-0002-1046-2829, Fenoy, Albert J., Balakrishnan, Shankar, Zirh, Ali T., Cevik, Aslihan, Tomar, Amit Kumar and Ouerchefani, Naoufel (2021). Surgical Management for Dystonia: Efficacy of Deep Brain Stimulation in the Long Term. Neurol. Int., 13 (3). S. 371 - 387. BASEL: MDPI. ISSN 2035-8377

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Abstract

Introduction: Dystonia is a movement disorder substantially affecting the quality of life. Botulinum Neurotoxin (BoNT) is used intramuscularly as a treatment for dystonia; however, not all dystonia patients respond to this treatment. Deep brain stimulation (DBS) is an established treatment for Parkinson's disease (PD) and essential tremor, but it can help in dystonia as well. Objectives: We studied a total of 67 dystonia patients who were treated with DBS over a period of 7 years to find out the long-term efficacy of DBS in those patients. First, we calculated patient improvement in post-surgery follow-up programs using the Global Dystonia Severity scale (GDS) and Burke-Fahn-Marsden dystonia rating scale (BFMDRS). Secondly, we analyzed the scales scores to see if there was any statistical significance. Methods: In our study we analyzed patients with ages from 38 to 78 years with dystonia who underwent DBS surgery between January 2014 and December 2020 in four different centers (India, Kuwait, Egypt, and Turkey). The motor response to DBS surgery was retrospectively measured for each patient during every follow-up visit using the GDS and the BFMDRS scales. Results: Five to 7 years post-DBS, the mean reduction in the GDS score was 30 +/- 1.0 and for the BFMDRS score 26 +/- 1.0. The longitudinal change in scores at 12 and 24 months post-op was also significant with mean reductions in GDS and BFMDRS scores of 68 +/- 1.0 and 56 +/- 1.0, respectively. The p-values were <0.05 for our post-DBS dystonia patients. Conclusions: This study illustrates DBS is an established, effective treatment option for patients with different dystonias, such as generalized, cervical, and various brain pathology-induced dystonias. Although symptoms are not completely eliminated, continuous improvements are noticed throughout the post-stimulation time frame.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kamel, Walaa A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Majumdar, Pritam UNSPECIFIED UNSPECIFIED UNSPECIFIED Matis, Georgios UNSPECIFIED orcid.org/0000-0002-1046-2829 UNSPECIFIED Fenoy, Albert J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Balakrishnan, Shankar UNSPECIFIED UNSPECIFIED UNSPECIFIED Zirh, Ali T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cevik, Aslihan UNSPECIFIED UNSPECIFIED UNSPECIFIED Tomar, Amit Kumar UNSPECIFIED UNSPECIFIED UNSPECIFIED Ouerchefani, Naoufel UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-598135
DOI:	10.3390/neurolint13030037
Journal or Publication Title:	Neurol. Int.
Volume:	13
Number:	3
Page Range:	S. 371 - 387
Date:	2021
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2035-8377
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language QUALITY-OF-LIFE; PALLIDAL STIMULATION; CERVICAL DYSTONIA; FOLLOW-UP; GENERALIZED DYSTONIA; IDIOPATHIC DYSTONIA; NEUROSTIMULATION; DIAGNOSIS; LOCATION; DBS Multiple languages Clinical Neurology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59813