Universität zu Köln

Melo van Lent, Debora ORCID: 0000-0002-7392-9289, Egert, Sarah, Wolfsgruber, Steffen, Kleineidam, Luca, Weinhold, Leonie ORCID: 0000-0002-9194-9427, Wagner-Thelen, Holger, Maier, Wolfgang ORCID: 0000-0003-1016-8539, Jessen, Frank ORCID: 0000-0003-1067-2102, Ramirez, Alfredo ORCID: 0000-0003-4991-763X, Schmid, Matthias ORCID: 0000-0002-0788-0317, Scherer, Martin, Riedel-Heller, Steffi G. and Wagner, Michael ORCID: 0000-0003-2589-6440 (2021). Eicosapentaenoic Acid Is Associated with Decreased Incidence of Alzheimer's Dementia in the Oldest Old. Nutrients, 13 (2). BASEL: MDPI. ISSN 2072-6643

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Abstract

Background. Omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFAs) may have different effects on cognitive health due to their anti- or pro-inflammatory properties. Methods. We aimed to prospectively examine the relationships between n-3 and n-6 PUFA contents in serum phospholipids with incident all-cause dementia and Alzheimer's disease dementia (AD). We included 1264 non-demented participants aged 84 +/- 3 years from the German Study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe) multicenter-cohort study. We investigated whether fatty acid concentrations in serum phospholipids, especially eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), alpha-linolenic acid (ALA), linoleic acid (LA), dihomo-gamma-linolenic acid (DGLA), and arachidonic acid (AA), were associated with risk of incident all-cause dementia and AD. Results. During the follow-up window of seven years, 233 participants developed dementia. Higher concentrations of EPA were associated with a lower incidence of AD (hazard ratio (HR) 0.76 (95% CI 0.63; 0.93)). We also observed that higher concentrations of EPA were associated with a decreased risk for all-cause dementia (HR 0.76 (95% CI 0.61; 0.94)) and AD (HR 0.66 (95% CI 0.51; 0.85)) among apolipoprotein E epsilon 4 (APOE epsilon 4) non-carriers but not among APOE epsilon 4 carriers. No other fatty acids were significantly associated with AD or dementia. Conclusions. Higher concentrations of EPA were associated with a lower risk of incident AD. This further supports a beneficial role of n-3 PUFAs for cognitive health in old age.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Melo van Lent, Debora UNSPECIFIED orcid.org/0000-0002-7392-9289 UNSPECIFIED Egert, Sarah UNSPECIFIED UNSPECIFIED UNSPECIFIED Wolfsgruber, Steffen UNSPECIFIED UNSPECIFIED UNSPECIFIED Kleineidam, Luca UNSPECIFIED UNSPECIFIED UNSPECIFIED Weinhold, Leonie UNSPECIFIED orcid.org/0000-0002-9194-9427 UNSPECIFIED Wagner-Thelen, Holger UNSPECIFIED UNSPECIFIED UNSPECIFIED Maier, Wolfgang UNSPECIFIED orcid.org/0000-0003-1016-8539 UNSPECIFIED Jessen, Frank UNSPECIFIED orcid.org/0000-0003-1067-2102 UNSPECIFIED Ramirez, Alfredo UNSPECIFIED orcid.org/0000-0003-4991-763X UNSPECIFIED Schmid, Matthias UNSPECIFIED orcid.org/0000-0002-0788-0317 UNSPECIFIED Scherer, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Riedel-Heller, Steffi G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wagner, Michael UNSPECIFIED orcid.org/0000-0003-2589-6440 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-598253
DOI:	10.3390/nu13020461
Journal or Publication Title:	Nutrients
Volume:	13
Number:	2
Date:	2021
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2072-6643
Language:	English
Faculty:	Faculty of Medicine
Divisions:	Faculty of Medicine > Sonstiges > Zentrum für Versorgungsforschung Köln
Subjects:	Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language Nutrition & Dietetics Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/59825