Universität zu Köln

Kim, Mi-Ran, Oji, Vinzenz, Valentin, Frederic, Traupe, Heiko, Nofer, Jerzy-Roch, Hausser, Ingrid, Hennies, Hans Christian, Eckl, Katja, Wudy, Stefan A., Sanchez-Guijo, Alberto, Kerschke, Laura, Fischer, Judith and Suessmuth, Kira (2021). Vitamin D Status in Distinct Types of Ichthyosis: Importance of Genetic Type and Severity of Scaling. Acta Derm.-Venereol., 101. UPPSALA: ACTA DERMATO-VENEREOLOGICA. ISSN 1651-2057

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Abstract

Data on vitamin D status of patients with inherited ichthyosis in Europe is scarce and unspecific concerning the genetic subtype. This study determined serum levels of 25-hydroxyvitamin D3 (25(OH)D3) in 87 patients with ichthyosis; 69 patients were additionally analysed for parathyroid hormone. Vitamin D deficiency was pronounced in keratinopathic ichthyosis (n = 17; median 25(OH)D3: 10.5 ng/ml), harlequin ichthyosis (n = 2;7.0 ng/ml) and rare syndromic subtypes (n = 3; 7.0 ng/ml). Vitamin D levels were reduced in TG1-proficient lamellar ichthyosis (n = 15; 8.9 ng/ml), TG1-deficient lamellar ichthyosis (n = 12; 11.7 ng/ml), congenital ichthyosiform erythroderma (n = 13; 12.4 ng/ml), Netherton syndrome (n = 7; 10.7 ng/ml) and X-linked ichthyosis (n = 8; 13.9 ng/ml). In ichthyosis vulgaris 25(OH)D3 levels were higher (n = 10; 19.7 ng/ml). Parathyroid hormone was elevated in 12 patients. Low 25(OH)D3 levels were associated with high severity of scaling (p = 0.03) implicating scaling as a risk factor for vitamin D deficiency. Thus, this study supports our recent guidelines for ichthyoses, which recommend screening for and substituting of vitamin D deficiency.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kim, Mi-Ran UNSPECIFIED UNSPECIFIED UNSPECIFIED Oji, Vinzenz UNSPECIFIED UNSPECIFIED UNSPECIFIED Valentin, Frederic UNSPECIFIED UNSPECIFIED UNSPECIFIED Traupe, Heiko UNSPECIFIED UNSPECIFIED UNSPECIFIED Nofer, Jerzy-Roch UNSPECIFIED UNSPECIFIED UNSPECIFIED Hausser, Ingrid UNSPECIFIED UNSPECIFIED UNSPECIFIED Hennies, Hans Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Eckl, Katja UNSPECIFIED UNSPECIFIED UNSPECIFIED Wudy, Stefan A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sanchez-Guijo, Alberto UNSPECIFIED UNSPECIFIED UNSPECIFIED Kerschke, Laura UNSPECIFIED UNSPECIFIED UNSPECIFIED Fischer, Judith UNSPECIFIED UNSPECIFIED UNSPECIFIED Suessmuth, Kira UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-598359
DOI:	10.2340/00015555-3887
Journal or Publication Title:	Acta Derm.-Venereol.
Volume:	101
Date:	2021
Publisher:	ACTA DERMATO-VENEREOLOGICA
Place of Publication:	UPPSALA
ISSN:	1651-2057
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language D DEFICIENCY; CONGENITAL ICHTHYOSIS; FILAGGRIN DEFICIENCY; PARATHYROID-HORMONE; 25-HYDROXYVITAMIN D; FLG MUTATIONS; CHILDREN; SERUM; ERYTHRODERMA; VULGARIS Multiple languages Dermatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59835