Universität zu Köln

Rendenbach, Carsten ORCID: 0000-0002-9565-7640, Fischer, Heilwig, Kopp, Alexander ORCID: 0000-0001-8787-0401, Schmidt-Bleek, Katharina, Kreiker, Henri, Stumpp, Sabine, Thiele, Mario, Duda, Georg ORCID: 0000-0001-7605-3908, Hanken, Henning, Beck-Broichsitter, Benedicta ORCID: 0000-0003-4664-5966, Jung, Ole, Kroeger, Nadja, Smeets, Ralf and Heiland, Max ORCID: 0000-0002-4987-2913 (2021). Improved in vivo osseointegration and degradation behavior of PEO surface-modified WE43 magnesium plates and screws after 6 and 12 months. Mater. Sci. Eng. C-Mater. Biol. Appl., 129. AMSTERDAM: ELSEVIER. ISSN 1873-0191

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Abstract

Magnesium is a highly promising candidate with respect to its future use as a material for resorbable implants. When magnesium degrades, hydrogen gas is released. High doses of gas emergence are reported to impair osseointegration and may therefore lead to fixation failure. The successful delay and reduction of the degradation rate by applying plasma electrolytic oxidation (PEO) as a post processing surface modification method for magnesium alloy has recently been demonstrated. The aim of this study was thus to compare the degradation behavior of a WE43-based plate system with and without respective PEO surface modification and to further investigate osseointegration, as well as the resulting effects on the surrounding bony tissue of both variants in a miniature pig model. WE43 magnesium screws and plates without (WE43) and with PEO surface modification (WE43-PEO) were implanted in long bones of Go spacing diaeresis ttingen Miniature Pigs. At six and twelve months after surgery, micro-CT and histomorphometric analysis was performed. Residual screw volume (SV/TV; WE43: 28.8 +/- 21.1%; WE43-PEO: 62.9 +/- 31.0%; p = 0.027) and bone implant contact area (BIC; WE43: 18.1 +/- 21.7%; WE43-PEO: 51.6 +/- 27.7%; p = 0.015) were increased after six months among the PEO-modified implants. Also, surrounding bone density within the cortical bone was not affected by surface modification (BVTV; WE43: 76.7 +/- 13.1%; WE43-PEO: 73.1 +/- 16.2%; p = 0.732). Intramedullar (BV/TV; WE43: 33.2 +/- 16.7%; WE43-PEO 18.4 +/- 9.0%; p = 0.047) and subperiosteal (bone area; WE43: 2.6 +/- 3.4 mm2; WE43-PEO: 6,9 +/- 5.2 mm2; p = 0.049) new bone formation was found for both, surface-modified and nonsurface-modified groups. After twelve months, no significant differences of SV/TV and BV/TV were found between the two groups. PEO surface modification of WE43 plate systems improved osseointegration and significantly reduced the degradation rate within the first six months in vivo. Osteoconductive and osteogenic stimulation by WE43 magnesium implants led to overall increased bone growth, when prior PEO surface modification was conducted.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rendenbach, Carsten UNSPECIFIED orcid.org/0000-0002-9565-7640 UNSPECIFIED Fischer, Heilwig UNSPECIFIED UNSPECIFIED UNSPECIFIED Kopp, Alexander UNSPECIFIED orcid.org/0000-0001-8787-0401 UNSPECIFIED Schmidt-Bleek, Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreiker, Henri UNSPECIFIED UNSPECIFIED UNSPECIFIED Stumpp, Sabine UNSPECIFIED UNSPECIFIED UNSPECIFIED Thiele, Mario UNSPECIFIED UNSPECIFIED UNSPECIFIED Duda, Georg UNSPECIFIED orcid.org/0000-0001-7605-3908 UNSPECIFIED Hanken, Henning UNSPECIFIED UNSPECIFIED UNSPECIFIED Beck-Broichsitter, Benedicta UNSPECIFIED orcid.org/0000-0003-4664-5966 UNSPECIFIED Jung, Ole UNSPECIFIED UNSPECIFIED UNSPECIFIED Kroeger, Nadja UNSPECIFIED UNSPECIFIED UNSPECIFIED Smeets, Ralf UNSPECIFIED UNSPECIFIED UNSPECIFIED Heiland, Max UNSPECIFIED orcid.org/0000-0002-4987-2913 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-598923
DOI:	10.1016/j.msec.2021.112380
Journal or Publication Title:	Mater. Sci. Eng. C-Mater. Biol. Appl.
Volume:	129
Date:	2021
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	1873-0191
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ALLOYS; OSTEOSYNTHESIS; BIOMATERIALS; VITRO; FIXATION; REMOVAL; GROWTH; BODY Multiple languages Materials Science, Biomaterials Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/59892